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首页> 外文期刊>Russian journal of marine biology >The Effects of the Lipid Complex of Extract from the Marine Red Alga Ahnfeltia tobuchiensis (Kanno et Matsubara) Makienko on the Biochemical Parameters of Blood Plasma and Erythrocyte Membranes during Experimental Stress Exposure
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The Effects of the Lipid Complex of Extract from the Marine Red Alga Ahnfeltia tobuchiensis (Kanno et Matsubara) Makienko on the Biochemical Parameters of Blood Plasma and Erythrocyte Membranes during Experimental Stress Exposure

机译：从海洋红藻Ahnfeltia tobuchichiensis（Kanno et Matsubara）Makienko对实验压力暴露过程中血浆和红细胞膜生化参数的脂质复合物的影响

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摘要

The present study considers effects of a lipid complex isolated from the aqueous-ethanol (70%) extract from the marine red algaAhnfeltia tobuchiensisand effects of the Essentiale commercial preparation on the biochemical parameters of blood plasma and erythrocyte membranes of mice exposed to experimental stress (suspension by the scruff of the neck). The pharmacological effect of the lipid complex fromA. tobuchiensisis manifested as elimination of dyslipidemia and hypercholesterolemia accompanied by a reduction in the levels of total lipids and low-density lipoproteins, an increase in the level of high-density lipoproteins in plasma, and normalization of the cholesterol/phospholipid ratio and the phospholipid composition of erythrocyte membranes. TheAhnfeltiaextract was not inferior to the Essentiale reference preparation in terms of effectiveness and was even superior in the potential to restore the blood lipid composition and the phospholipid fraction ratio in erythrocyte membranes. The pharmacological effect of the lipid complex fromAhnfeltiais determined by the action of its phospholipid fractions and polyunsaturated n-6 and n-3 fatty acids, which contribute to the utilization of cholesterol from membranes and the enhancement of the lipoprotein ratio towards increase in high-density lipoproteins and are also involved in erythrocyte membrane repair.
机译：本研究考虑了从乙醇水溶液中分离的脂质复合物的影响来自海洋红藻氨酰·米菌毒素的Essentiale商业制剂对实验胁迫（悬浮液）的血浆和红细胞膜的生化参数的影响（悬浮液）通过颈部颈背）。脂质复合物的药理作用。表现为消除血脂血症和高胆固醇血症的消除伴随着总脂质和低密度脂蛋白水平的降低，血浆中高密度脂蛋白水平的增加，以及胆固醇/磷脂比的标准化和磷脂组合物红细胞膜。 TheahnfeltiaExtract在有效性方面并不差不等，并且甚至在恢复血液脂质组合物和红细胞膜中的磷脂级分比的可能性。脂质复合物的药理作用由其磷脂级分和多不饱和N-6和N-3脂肪酸的作用决定，这有助于利用诸如膜的胆固醇和脂蛋白比率升高高密度的增加脂蛋白和也参与红细胞膜修复。

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