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首页> 外文期刊>Schizophrenia Bulletin >Trimethoprim as Adjuvant Treatment in Schizophrenia: A Double-Blind, Randomized, Placebo-Controlled Clinical Trial
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Trimethoprim as Adjuvant Treatment in Schizophrenia: A Double-Blind, Randomized, Placebo-Controlled Clinical Trial

机译：甲氧苄啶作为精神分裂症的辅助治疗：一项双盲，随机，安慰剂对照的临床试验。

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Various infectious agents, such as Toxoplasma gondii, have been hypothesized to be potentially relevant etiological factors in the onset of some cases of schizophrenia. We conducted a randomized, double-blind, placebo-controlled treatment trial in an attempt to explore the hypothesis that the symptoms of schizophrenia may be related to infection of the central nervous system with toxoplasma gondii. Systematically selected patients with ongoing and at least moderately severe schizophrenia from Butajira, in rural Ethiopia, were randomly allocated to trimethoprim or placebo, which were added on to participants' regular antipsychotic treatments. Trial treatments were given for 6 months. The Positive and Negative Syndrome Scale (PANSS) was used to assess outcome. Ninety-one patients were included in the study, with 80 cases (87.9%) positive for T. gondii immunoglobulin G antibody. Seventy-nine subjects (87.0%) completed the trial. The mean age of subjects was 35.3 (SD = 8.0) years, with a mean duration of illness of 13.2 (SD = 6.7) years. Both treatment groups showed significant reduction in the overall PANSS score with no significant between-group difference. In this sample of patients with chronic schizophrenia, trimethoprim used as adjuvant treatment is not superior to placebo. However, it is not possible to draw firm conclusion regarding the etiological role of toxoplasmosis on schizophrenia based on this study because the timing and the postulated mechanisms through which toxoplasmosis produces schizophrenia are variable.
机译：在某些精神分裂症病例中，已假设各种传染原，例如弓形虫，可能是相关的病因。我们进行了一项随机，双盲，安慰剂对照的治疗试验，以试图探索精神分裂症症状可能与弓形虫感染中枢神经系统有关的假说。系统地选择埃塞俄比亚农村地区布塔吉拉患有持续和至少中度重度精神分裂症的患者，随机分配甲氧苄啶或安慰剂，并加入参与者的常规抗精神病药物治疗中。进行了6个月的试用治疗。阳性和阴性综合征量表（PANSS）用于评估结局。该研究包括91名患者，其中80例（87.9％）的弓形虫免疫球蛋白G抗体阳性。 79名受试者（87.0％）完成了试验。受试者的平均年龄为35.3（SD = 8.0）年，平均病程为13.2（SD = 6.7）年。两个治疗组均显示总体PANSS得分显着降低，组间无显着差异。在这个慢性精神分裂症患者的样本中，甲氧苄啶作为辅助治疗并不优于安慰剂。然而，基于这项研究，不可能就弓形虫病对精神分裂症的病因学作用得出确切的结论，因为弓形虫病产生精神分裂症的时间和推测的机制是可变的。

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