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首页> 外文期刊>Science of advanced materials >Affinity Characteristics of Histone-Derived Peptide Layer by Memory Charging Effect Using Chromatin Protein Conjugated Gold Nanoparticles
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Affinity Characteristics of Histone-Derived Peptide Layer by Memory Charging Effect Using Chromatin Protein Conjugated Gold Nanoparticles

机译：染色质蛋白共轭金纳米粒子通过记忆充电效应的组蛋白衍生肽层的亲和特性。

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摘要

In this study, organic-based electronic memory structure using selective recognition between histone H3 peptide and heterochromatin protein 1 (HP1) conjugated gold nanoparticles (Au NPs) as charge storage elements is demonstrated. HP1 conjugated Au NPs were formed as self-assembly monolayers (SAMs) on two different H3 peptide layers having different binding affinities to HP1. The different binding affinity was originated from methylation at 9th amino acid of lysine of the H3 peptide. Memory device was introduced in the structure of metal-pentacene-insulator-silicon (MPIS) capacitor where Au NPs SAMs were embedded between pentacene and insulator. Dielectric SiO_2 layers were surface modified by 3-aminopropyl triethoxysi-lane (APTES) and 1-ethyl-3-(3-dimethylaminopropyl)-carbodiimide/N-hydroxysuccinimide (EDC/NHS) coupling chemistry to immobilize two H3 peptides, methylated at lysine 9 (Met-Lys9) or unmethylated (Unmet-Lys9). The capacitance versus voltage (C-V) curves from the memory devices exhibited two distinct hysteresis of flatband voltage shifts, which demonstrated separate affinity of HP1 to H3 peptide Met-Lys9 and Unmet-Lys9, respectively.
机译：在这项研究中，使用组蛋白H3肽和异染色质蛋白1（HP1）共轭金纳米粒子（Au NPs）之间的选择性识别作为电荷存储元件的基于有机物的电子存储结构得到了证明。与HP1结合的Au NP以自组装单层（SAMs）的形式形成在对HP1具有不同结合亲和力的两个不同的H3肽层上。不同的结合亲和力源自H3肽的赖氨酸的第9个氨基酸处的甲基化。在金属并五苯绝缘体硅（MPIS）电容器的结构中引入了存储器件，其中金NPs SAMs嵌入并五苯与绝缘体之间。用3-氨基丙基三乙氧基硅烷（APTES）和1-乙基-3-（3-二甲基氨基丙基）-碳二亚胺/ N-羟基琥珀酰亚胺（EDC / NHS）偶联化学对介电SiO_2层进行表面改性，以固定两个在赖氨酸处甲基化的H3肽9（Met-Lys9）或未甲基化（Unmet-Lys9）。来自存储设备的电容与电压（C-V）曲线表现出两个不同的平坦带电压偏移滞后现象，这分别证明了HP1对H3肽Met-Lys9和Unmet-Lys9的独立亲和力。

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  • 来源
    《Science of advanced materials》 |2014年第11期|2478-2482|共5页
  • 作者

    Hunsang Jung; Yejin Kim; Jihee Jung; Dahye Kwon; Tae-Sik Yoon; Chi Jung Kang; Taek-Jin Kang; Hyun Ho Lee;

  • 作者单位

    Department of Chemical Engineering, Myongji University, Yongin 449-728, Republic of Korea;

    Department of Chemical Engineering, Myongji University, Yongin 449-728, Republic of Korea;

    Department of Chemical Engineering, Myongji University, Yongin 449-728, Republic of Korea;

    Department of Chemical Engineering, Myongji University, Yongin 449-728, Republic of Korea;

    Department of Material Science Engineering, Myongji University, Yongin 449-728, Republic of Korea;

    Department of Physics, Myongji University, Yongin 449-728, Republic of Korea;

    Department of Chemical and Biochemical Engineering, Dongguk University, Seoul 100-715, Republic of Korea;

    Department of Chemical Engineering, Myongji University, Yongin 449-728, Republic of Korea;

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  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类
  • 关键词

    Bio-Inspired System; Self-Assembly Monolayer; Au Nanoparticle; Organic Device;

    机译：生物启发系统;自组装单层;金纳米粒子有机装置;

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