...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Science of advanced materials >Anti-Inflammatory and Photoprotective Effects of Magnetic Nanoparticles Against Ultraviolet-Induced Photoaging in Human Skin Cells
【24h】

Anti-Inflammatory and Photoprotective Effects of Magnetic Nanoparticles Against Ultraviolet-Induced Photoaging in Human Skin Cells

机译：磁性纳米粒子对人类皮肤细胞中紫外线诱导的光老化的抗炎和光保护作用。

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Magnetic nanoparticles (MNPs) have been employed in a variety of applications, including heat carriers, printing, recording, polishing media, and in the manufacture of bearings, seals, and lubricants. In the present study, we investigated the anti-inflammatory and protective effects of MNPs against ultraviolet-induced photoaging in human skin cells. The characteristic color of MNPs was brown. Scanning electron microscopy showed that the nanoparticles were non-uniform with an average particle size of 17-20 nm in size. Further testing showed that the onset of the MNPs' transmittance against ultraviolet (UV) decreased at a wavelength of 400 nm. Pretreatment with MNPs inhibited the production of nitric oxide by 32%, when compared to the UV-irradiated cells. The secretion levels of IL-6 in HS68 cells exposed to Fe-1 (100 μg/mL) and Fe-2 (100 μg/mL) decreased by 44.95% and 78.65%, respectively, compared to the UV-irradiated control cells. Additionally, the level of TNF-α in HS68 cells exposed to Fe-1 and Fe-2 (100 μg/mL) significantly decreased by 44.32% and 57.52%, respectively. These results suggest that γ-Fe_2O_3 nanoparticles have photoprotective and anti-inflammatory properties. These results show that such MNPs could be used as agents against photoaging.
机译：磁性纳米颗粒（MNP）已用于多种应用，包括热载体，印刷，记录，抛光介质，以及轴承，密封件和润滑剂的制造。在本研究中，我们研究了MNP对人类皮肤细胞中紫外线诱导的光老化的抗炎和保护作用。 MNP的特征色是棕色。扫描电子显微镜显示纳米颗粒是不均匀的，平均粒径为17-20nm。进一步的测试表明，MNPs对紫外线（UV）的透射率在400 nm波长处降低。与紫外线照射的细胞相比，用MNP进行的预处理将一​​氧化氮的产生抑制了32％。与紫外线照射的对照细胞相比，暴露于Fe-1（100μg/ mL）和Fe-2（100μg/ mL）的HS68细胞中IL-6的分泌水平分别降低了44.95％和78.65％。此外，暴露于Fe-1和Fe-2（100μg/ mL）的HS68细胞中的TNF-α水平分别显着降低了44.32％和57.52％。这些结果表明，γ-Fe_2O_3纳米粒子具有光保护和抗炎特性。这些结果表明，这种MNP可以用作抗光老化剂。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号