MOLECULAR PARADIGM OF DISEASES OF CONFORMATION ALTERNATIONS IN PROTEINS : PRIONS AND RELATED DISEASES

SRIBIR SEN

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MOLECULAR PARADIGM OF DISEASES OF CONFORMATION ALTERNATIONS IN PROTEINS : PRIONS AND RELATED DISEASES

机译：蛋白质构象变异疾病的分子范式：普氏和相关疾病

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In mammalian system conformationally altered proteins are the causative agents of number of critical diseases. These diseases are classically known as prion related diseases. Importantly, mechanisms of such altered protein generation is poorly understood, even though, these diseases are the major problems of today's clinical world. Conformational alterations of proteins happen because of innumerable reasons. Knowledge on therapeutic aspects of these diseases is limited and is yet to find out suitable clues in combating them. However, many interesting findings have been generated that show hopes to encounter with these diseases.

机译：在哺乳动物系统中，构象改变的蛋白质是许多严重疾病的病原体。这些疾病在传统上被称为病毒相关疾病。重要的是，尽管这些疾病是当今临床世界的主要问题，但人们对这种蛋白质生成改变的机制知之甚少。蛋白质的构象改变是由于无数原因而发生的。关于这些疾病的治疗方面的知识是有限的，并且尚未找到与这些疾病作斗争的适当线索。然而，已经产生了许多有趣的发现，表明希望与这些疾病相遇。

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《Science and Culture》 |2007年第8期|213-219|共7页
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SRIBIR SEN;
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Burdwan Institute of Management and Computer Science, Department of Biotechnology and Biochemistry, Hatudewan, Burdwan 713 101, West Bengal, India;

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正文语种 eng
中图分类自然科学总论;
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1. One gene, two diseases and three conformations: molecular dynamics simulations of mutants of human prion protein at room temperature and elevated temperatures. [J] . Shamsir MS, Dalby AR Proteins: Structure, Function, and Genetics . 2005,第2期

机译：一种基因，两种疾病和三种构象：人类病毒蛋白突变体在室温和高温下的分子动力学模拟。
2. Molecular structures and structural dynamics of prion proteins and prions: mechanism underlying the resistance to prion diseases [J] . Anthony J. Duben Computing reviews . 2016,第12期

机译：pr病毒蛋白和病毒的分子结构和结构动力学：抵抗病毒疾病的潜在机制
3. Gerstmann-Str?ussler-Scheinker Disease and “Anchorless Prion Protein” Mice Share Prion Conformational Properties Diverging from Sporadic Creutzfeldt-Jakob Disease [J] . Gianluigi Zanusso, Michele Fiorini, Sergio Ferrari, The Journal of biological chemistry . 2014,第8期

机译：Gerstmann-str？Ussler-scheinker病和“锚朊蛋白”小鼠股票朊病毒构象性质从孢子菌克雷托茨Feldt-jakob疾病发散
4. Role of Prion Protein Anchoring in Pathogenesis of Prion Diseases [C] . B. Chesebro Annual Meeting of the American Society for Veterinary Clinical Pathology . 2007

机译：朊蛋白锚定在朊病毒疾病发病机制中的作用
5. Conformation based reagents for the detection of disease-associated prion protein. [D] . Hatcher, Kristen-Louise. 2009

机译：基于构象的试剂，用于检测与疾病相关的pr病毒蛋白。
6. Gerstmann-Sträussler-Scheinker Disease and Anchorless Prion Protein Mice Share Prion Conformational Properties Diverging from Sporadic Creutzfeldt-Jakob Disease [O] . Gianluigi Zanusso, Michele Fiorini, Sergio Ferrari, 2014

机译：Gerstmann-Sträussler-Scheinker病和无锚Pri蛋白小鼠的偶发构象特性与散发的Creutzfeldt-Jakob病不同
7. One gene, two diseases and three conformations: molecular dynamics simulations of mutants of human prion protein at room temperature and elevated temperatures. [O] . Shamsir Mohd Shahir, Dalby Andrew 2005

机译：一种基因，两种疾病和三种构象：人类病毒蛋白突变体在室温和高温下的分子动力学模拟。

MOLECULAR PARADIGM OF DISEASES OF CONFORMATION ALTERNATIONS IN PROTEINS : PRIONS AND RELATED DISEASES

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