SPECTROPHOTOMETRIC DETERMINATION OF TRANDALOPRIL WITH NQS IN PHARMACEUTICAL FORMULATIONS

A.V. SUBBAYAMMA; PROF. C. RAMBABU

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SPECTROPHOTOMETRIC DETERMINATION OF TRANDALOPRIL WITH NQS IN PHARMACEUTICAL FORMULATIONS

机译：药学配方中NQS的分光光度法测定三萘普利。

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Trandalopril contains a secondary amino group and permits the development of a spectrophotometric method with 1, 2 napthaquinone-4-sulfonic acid (NQS) through the Nucleophilic substitution. In the case of secondary amine, only the quinine imine structure can be taken into account. The absorbance was measured at 480 nm. No interference was observed from the usually existing additives in pharmaceutical formulations and the applicability of the method was examined by analyzing formulations. The results of analysis have been validated statistically and by recovery studies.

机译：曲安普利含有一个仲氨基，并允许通过亲核取代法用1、2萘醌-4-磺酸（NQS）进行分光光度法的开发。在仲胺的情况下，仅可考虑奎宁亚胺结构。在480nm处测量吸光度。没有观察到药物制剂中通常存在的添加剂的干扰，并且通过分析制剂检查了该方法的适用性。分析结果已通过统计学和回收率研究验证。

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来源
《Acta Ciencia Indica》 |2011年第3期|p.173-177|共5页
作者
A.V. SUBBAYAMMA; PROF. C. RAMBABU;
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作者单位

Department of Chemistry, SI Theresa's College for Women, Eluru (A. P.), India;

Department of Chemistry, Acliarya Nagarjuna University P.G.Centre, Nuzvid, Krishna Dist. (A.P), India;

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正文语种 eng
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spectrophotometry; 1, 2 naphthaquinone-4- sulfonic acid (NQS); trandalopril;

机译：分光光度法1;2萘醌-4-磺酸（NQS）;来那普利;

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SPECTROPHOTOMETRIC DETERMINATION OF TRANDALOPRIL WITH NQS IN PHARMACEUTICAL FORMULATIONS

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