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Evaluation studies of a sensing technique for electrostatic charge polarity of pharmaceutical particulates

机译：药物颗粒静电荷极性传感技术的评估研究

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摘要

Electrostatic charge due to inter-particle and particle-to-wall contacts may generate significant hazards during the processing of particulates within the pharmaceutical industry. Although charge behaviour of particulates is erratic and not easy to predict, it would be desirable to characterise the tendency of tribocharging prior to manufacturing. The work reported in this study concentrates on a new and novel technique for the detection of the active ingredient and excipient in a bipolar material. Three different case studies are presented for demonstration of the applicability of the method in different practical situations. Work confirmed through an experimental rig set-up indicates that materials that accumulate opposite charge via contact and rubbing can be detected from their charge sign as well as their relative magnitude. The results reported clearly demonstrated that the developed method for charge characterisation is a useful tool to understand how the charges are distributed in a population of particles showing a number of advantages over conventional methods.
机译：由于颗粒间以及颗粒与壁之间的接触而产生的静电电荷可能会在制药行业内处理颗粒期间产生重大危害。尽管微粒的带电行为是不稳定的并且不容易预测，但是在制造之前表征摩擦带电的趋势将是合乎需要的。本研究报告的工作集中在检测双极性物质中活性成分和赋形剂的新技术上。提出了三个不同的案例研究，以证明该方法在不同实际情况下的适用性。通过实验装置的设置确认的工作表明，通过接触和摩擦累积相反电荷的材料可以从其电荷符号及其相对大小中检测到。报告的结果清楚地表明，用于电荷表征的已开发方法是了解电荷如何在粒子群中分布的有用工具，与常规方法相比，具有许多优势。

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