Researchers close in on ricin antidote

MEGHAN ROSEN

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Researchers close in on ricin antidote

机译：研究人员研究了蓖麻毒素解毒剂

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It has been used by an assassin wielding an umbrella gun and sent in a suspicious letter to a president. Ricin, the potent toxin and bioterrorism agent, has no antidote and can cause death within days. But a cocktail of antibodies could one day offer victims at least a slim window for treatment. A new study presented February 7 describes a ricin antidote that, in mice, works even days after exposure to the toxin. Another new study, presented the same day, offers a potential explanation for how such an antidote might work. Doctors need some way to deal with ricin poisoning, said Patrick Cherubin, a cell biologist at the University of Central Florida in Orlando. Immunologist Nicholas Mantis of the New York State Department of Health in Albany agreed: "There is no specific treatment or therapy whatsoever."

机译：刺客手持一把雨伞枪使用了它，并向总统发送了可疑信。蓖麻毒素（Ricin）是有效的毒素和生物恐怖剂，没有解毒剂，可在数天内导致死亡。但是有一天，抗体混合物可以为受害者提供至少一个狭窄的治疗窗口。 2月7日发表的一项新研究描述了一种蓖麻毒素解毒剂，这种毒素在小鼠中即使暴露于毒素后数天也能起作用。当天发表的另一项新研究为这种解毒剂如何发挥作用提供了潜在的解释。奥兰多中央佛罗里达大学的细胞生物学家Patrick Cherubin说，医生需要某种方法来处理蓖麻毒素中毒。纽约州卫生署的免疫学家尼古拉斯·曼蒂斯（Nicholas Mantis）同意：“没有任何具体的治疗方法。”

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《Science news》 |2017年第4期|14-15|共2页
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MEGHAN ROSEN;
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1. Researchers seek new snakebite antidotes that are easier to make and deploy [J] . Chemical Weekly group Chemical Weekly . 2019,第28期

机译：研究人员寻求更易于制作和部署的新蛇咬的解毒剂
2. The phenotype of mutations of the base-pair C2658.G2663 that closes the tetraloop in the sarcin/ricin domain of Escherichia coli 23 S ribosomal RNA. [J] . Chan YL, Sitikov AS, Wool IG Journal of Molecular Biology . 2000,第5期

机译：封闭大肠杆菌23 S核糖体RNA的sarcin / ricin域中四环的碱基对C2658.G2663的突变表型。
3. The ribosomal RNA identity elements for ricin and for α-sarcin: mutations in the putative CG pair that closes a GAGA tetraloop [J] . Anton Glück, Ira G. Wool, Yaeta Endo Nucleic acids research . 1994,第3期

机译：蓖麻蛋白和α-sarcin的核糖体RNA鉴定元件：推定的CG对中的突变，其关闭了GAGA四环
4. Howard Brenner: Visionary researcher, profound scholar and close friend. [C] . Andreas Acrivos AIChE Annual Meeting . 2014

机译：Howard Brenner：Visionary研究员，深刻的学者和亲密的朋友。
5. Characterization of Anti-Ricin Monoclonal Antibodies and the Construction of a Chimeric Murine-Human IgG2/K Anti-Ricin Monoclonal Antibody [D] . Vendramelli, Robert Matthew 2011

机译：抗蓖麻毒蛋白单克隆抗体的表征和鼠/人IgG2 / K嵌合抗蓖麻毒蛋白单克隆抗体的构建
6. The ribosomal RNA identity elements for ricin and for alpha-sarcin: mutations in the putative CG pair that closes a GAGA tetraloop. [O] . A Glück, Y Endo, I G Wool 1994

机译：蓖麻蛋白和α-sarcin的核糖体RNA身份元件：推定的CG对中的突变其关闭了GAGA四环。
7. Covid-19: Researchers question policy of closing schools after finding under 20s have low susceptibility to virus [O] . Ingrid Torjesen 2020

机译：Covid-19：研究人员在20多岁以下发现后的闭幕学校的问题对病毒的敏感性低
8. Antidotes for Ricin Intoxication. Effects of Ricin on the Vascular Neuroeffector System. [R] . Robinson, C. P., Christiansen, V. J., Hsu, C. H., 1992

机译：蓖麻毒素中毒的解毒剂。蓖麻毒素对血管神经效应系统的影响。

Researchers close in on ricin antidote

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