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DNA architecture, novel forensics offer new clues

机译:DNA体系结构,新颖的法医提供新线索

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It's one thing to catalog each chemical unit of DNA that makes up the human genome. It's another thing entirely to understand how that genetic material is folded up inside a living cell - and then decoded, manipulated and used. Achieving that understanding is the task of the architectural scholars of molecular biology, scientists who describe the loops and other yogic postures that DNA displays inside the cramped space of a cell's nucleus. This architecture has important implications for function, perhaps by arranging the genetic furniture to enable one cell to operate as a liver cell and another to work as a skin cell. But even this 3-D appreciation of the genome is limited, as science writing intern Sarah Schwartz writes on Page 18. Researchers must also contemplate a fourth dimension: genome morphing over time.
机译:对构成人类基因组的DNA的每个化学单元进行分类是一回事。完全理解遗传物质如何在活细胞内折叠然后被解码,操纵和使用是另一回事。实现这种理解是分子生物学的建筑学学者的任务,他们描述了DNA在细胞核狭窄空间内显示的循环和其他瑜伽姿势。这种结构可能会对功能产生重要影响,也许是通过安排遗传装备使一个细胞能够充当肝细胞而另一个细胞能够充当皮肤细胞。但是,正如科学写作实习生莎拉·施瓦茨(Sarah Schwartz)在第18页上所写的那样,即使对基因组的这种3-D欣赏也是有限的。研究人员还必须考虑第四个方面:基因组随时间的推移而发生变形。

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    《Science news》 |2015年第5期|2-2|共1页
  • 作者

    Eva Emerson;

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