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Responsibility and Laboratory Animal Research Governance

机译：责任与实验动物研究治理

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摘要

The use of animals in experiments and research remains highly contentious. Laboratory animal research governance provides guidance and regulatory frameworks to oversee the use and welfare of laboratory animals and relies heavily on the replacement, reduction, and refinement (3Rs) principles to demonstrate responsibility. However, the application of the 3Rs is criticized for being too narrow in focus and closing down societal concerns and political questions about the purpose of animal laboratory research. These critiques challenge the legitimacy of responsibility in laboratory animal research governance and call for new approaches. With the advent of the "Responsible Research and Innovation" (RRI) agenda, we investigate whether the notion of responsibility in the controversial area of animal research governance could be enhanced by examining the 3Rs through RRI. Our analysis reveals RRI has the potential to helpfully augment the 3Rs in three key ways: recognizing the need to include a broader range of experts and publics in animal research governance; emphasizing the importance for animal research scientists of taking societal, and not just role, responsibilities into account; and acknowledging the political questions animal research raises.
机译：在实验和研究中对动物的使用仍存在很大争议。实验动物研究治理提供指导和监管框架，以监督实验动物的使用和福利，并在很大程度上依赖于替代，减少和提炼（3R）原则来证明责任。但是，人们批评3R的应用范围太窄，并且关闭了有关动物实验室研究目的的社会关注和政治问题。这些批评挑战了实验室动物研究治理中责任的合法性，并呼吁采取新的方法。随着“负责任的研究与创新”（RRI）议程的出现，我们研究了有争议的动物研究治理领域的责任概念是否可以通过通过RRI检查3R来增强。我们的分析表明，RRI有潜力通过三个关键方式来帮助增强3R：认识到在动物研究治理中需要包括更多的专家和公众；强调对动物研究科学家而言，不仅要考虑社会责任，还要考虑其责任；并承认动物研究提出的政治问题。

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