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首页> 外文期刊>The Science of the Total Environment >Personal exposure to traffic-related air pollutants and relationships with respiratory symptoms and oxidative stress: A pilot cross-sectional study among urban green space workers
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Personal exposure to traffic-related air pollutants and relationships with respiratory symptoms and oxidative stress: A pilot cross-sectional study among urban green space workers

机译：个人与交通有关的空气污染物的暴露以及与呼吸道症状和氧化应激的关系：城市绿地工人的初步横断面研究

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Exposure to ambient air pollution has been associated with various adverse health effects including respiratory, cardiovascular and neurological diseases. Exposure data for some specific pollutants and settings are however still insufficient and mechanisms underlying negative health outcomes are not fully elucidated. This pilot study aimed to assess individual exposure to three traffic-related air pollutants, black carbon (BC), polycyclic aromatic hydrocarbons (PAHs) and benzene, and the relationship with respiratory and oxidative stress outcomes in a cross-sectional sample of 48 green space workers in Brussels. Belgium. Participants were followed during four consecutive working days in 2016-2017 during which their individual exposure to BC. PAHs, benzene and more generally air pollution was measured using aethalometers, urinary biomarkers (1-hydroxypyrene, 1-naphthol, 2-naphthol, S-phenylmercapturic acid) and questionnaires. Data on respiratory health and oxidative stress were collected using questionnaires and respiratory/urinary biomarkers (exhaled nitric oxide [NO], 8-hydroxydeoxyguanosine [8-OHdG]). Associations between exposure and health outcomes were investigated using comparison tests and linear regression models, after stratification by present-day smoking status. Spatial variation in BC exposure was high, with concentrations varying between 0.26 and 5.69 mu g/m(3). The highest levels were recorded during transport and, to a lesser extent, in green spaces located in the vicinity of roads with high traffic intensity. Concentrations of PAHs and benzene biomarkers did not systematically exceed the limits of detection. Among smokers, respiratory inflammation increased linearly with exposure to BC measured over the four days of follow-up (beta = 8.73, 95% Cl: 4.04, 13.41). Among non-smokers, oxidative stress increased linearly with BC measured on the fourth day (beta = 2.88, 95% Cl: 1.52, 424). Despite some limitations, this work supports the hypothesis that BC induces respiratory inflammation and oxidative stress. It also highlights the value of this compound as well as exhaled NO and urinary 8-OHdG biomarkers to detect early/mild effects of air pollution. (C) 2018 Elsevier B.V. All rights reserved.
机译：暴露于环境空气污染已与各种不良健康影响相关，包括呼吸系统疾病，心血管疾病和神经系统疾病。但是，某些特定污染物和环境的暴露数据仍然不足，并且尚未完全阐明造成负面健康后果的机制。这项初步研究旨在评估48个绿色空间横截面样本中三种与交通相关的空气污染物，黑碳（BC），多环芳烃（PAHs）和苯的个体暴露量，以及与呼吸和氧化应激结果的关系。布鲁塞尔的工人。比利时。在2016-2017年连续四个工作日中随访参与者，在此期间他们分别接触卑诗省。 PAHs，苯和更普遍的空气污染是通过测湿仪，尿液生物标志物（1-羟基py，1-萘酚，2-萘酚，S-苯基巯基酸）和问卷进行的。使用问卷和呼吸/泌尿生物标志物（呼出气一氧化氮[NO]，8-羟基脱氧鸟苷[8-OHdG]）收集有关呼吸健康和氧化应激的数据。根据当前吸烟状况进行分层后，使用比较测试和线性回归模型研究暴露与健康结果之间的关联。 BC暴露的空间变化很大，浓度在0.26和5.69μg / m之间变化（3）。在运输过程中记录了最高水平，在交通密度较高的道路附近的绿色空间中记录的水平较低。 PAHs和苯生物标志物的浓度没有系统地超过检测限。在吸烟者中，在随访的四天中，呼吸道炎症随暴露于BC呈线性增加（β= 8.73，95％Cl：4.04，13.41）。在非吸烟者中，氧化应激随第四天的BC呈线性增加（β= 2.88，95％Cl：1.52，424）。尽管有一些限制，但这项工作支持了BC引起呼吸道炎症和氧化应激这一假说。它还强调了该化合物以及呼出的NO和尿中的8-OHdG生物标志物对检测空气污染的早期/轻微影响的价值。 （C）2018 Elsevier B.V.保留所有权利。

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