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首页> 外文期刊>The Science of the Total Environment >Neem oil based nanopesticide as an environmentally-friendly formulation for applications in sustainable agriculture: An ecotoxicological perspective
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Neem oil based nanopesticide as an environmentally-friendly formulation for applications in sustainable agriculture: An ecotoxicological perspective

机译：印油基纳米农药作为可持续农业应用中的环保配方：生态毒理学观点

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摘要

Sustainable agriculture encourages practices that present low risks to the environment and human health. To this end, zein (corn protein) can be used to develop nanocanier systems capable of improving the physicochemical properties of biopesticides, reducing their possible toxicity. Neem oil extracted from the Azadiraclua indica tree contains many active ingredients including azadirachtin, which is the active ingredient in multiple commercially available biopesticides. In this study, we describe the preparation and characterization of neem oil-loaded zein nanoparticles, together with evaluation of their toxicity towards nontarget organisms, using Allium cepa, soil nitrogen cycle microbiota, and Caenorhabditis elegans aiming to achieve the safer by design strategy. the spherical nanoparticles showed an average diameter of 278 +/- 61.5 nm and a good stability during the experiments. In the toxicity assays with A. cepa, the neem oil-loaded zein nanoparticles mitigated the increase in the DNA relative damage index caused by the neem oil. Molecular genetic analysis of the soil nitrogen cycle microbiota revealed that neem oilloaded zein nanoparticles did not change the number of genes which encode nitrogen-fixing enzymes and denitrifying enzymes. In C. elegans, the neem oil-loaded win nanoparticles had no toxic effect, while neem oil interfered with pharyngeal pumping and GST-4 protein expression. These neem oil-loaded zein nanoparticles showed promising results in the toxicity studies, opening perspectives for its use in crop protection in organic agriculture. (C) 2019 Elsevier B.V. All rights reserved.
机译：可持续农业鼓励采取对环境和人类健康构成低风险的做法。为此，玉米醇溶蛋白（玉米蛋白）可用于开发能够改善生物农药的物理化学性质，降低其可能的毒性的纳米甘蔗体系。从印Az中提取的印em油含有许多活性成分，包括印a素，印a素是多种市售生物农药中的活性成分。在这项研究中，我们描述了印ne油玉米醇溶蛋白纳米粒子的制备和表征，并评估了其对非目标生物的毒性，使用葱属洋葱，土壤氮循环微生物和秀丽隐杆线虫（Caenorhabditis elegans），旨在通过设计策略实现更安全的目标。球形纳米颗粒的平均直径为278 +/- 61.5 nm，在实验过程中具有良好的稳定性。在用洋葱曲霉进行的毒性试验中，印-油负载的玉米醇溶蛋白纳米颗粒减轻了印the油引起的DNA相对损伤指数的增加。土壤氮循环菌群的分子遗传分析表明，印em油载玉米醇溶蛋白纳米粒不会改变编码固氮酶和反硝化酶的基因数量。在秀丽隐杆线虫中，印ne油负载的胜利纳米颗粒没有毒性作用，而印em油干扰咽泵和GST-4蛋白表达。这些印ne油装载的玉米醇溶蛋白纳米颗粒在毒性研究中显示出令人鼓舞的结果，为将其用于有机农业的作物保护开辟了前景。 （C）2019 Elsevier B.V.保留所有权利。

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  • 来源
    《The Science of the Total Environment》 |2019年第10期|57-67|共11页
  • 作者

    Pascoli Monica; Jacques Mauricio T.; Agarrayua Danielle A.; Avila Daiana S.; Lima Renata; Fraceto Leonardo F.;

  • 作者单位

    Sao Paulo State Univ UNESP, Inst Sci & Technol Sorocaba, Lab Environm Nanotechnol, Av 3 Marco,511, BR-18087180 Sorocaba, SP, Brazil;

    Fed Univ Pampa, Res Grp Biochem & Toxicol Caenorhabditis Elegans, BR 472,Km 585,Caixa Postal 118, BR-97501970 Uruguaiana, RS, Brazil;

    Fed Univ Pampa, Res Grp Biochem & Toxicol Caenorhabditis Elegans, BR 472,Km 585,Caixa Postal 118, BR-97501970 Uruguaiana, RS, Brazil;

    Fed Univ Pampa, Res Grp Biochem & Toxicol Caenorhabditis Elegans, BR 472,Km 585,Caixa Postal 118, BR-97501970 Uruguaiana, RS, Brazil;

    Univ Sorocaba, Lab Bioact Assessment & Toxicol Nanomat, Rodovia Raposo Tavares,Km 92-5, BR-18023000 Sorocaba, SP, Brazil;

    Sao Paulo State Univ UNESP, Inst Sci & Technol Sorocaba, Lab Environm Nanotechnol, Av 3 Marco,511, BR-18087180 Sorocaba, SP, Brazil;

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  • 正文语种 eng
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  • 关键词

    Zein nanoparticle; Nanopesticide; Biopesticide; Azadirachtin; Safer by design;

    机译：玉米醇溶蛋白纳米颗粒;农药;生物农药;印za素;设计安全;

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