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首页> 外文期刊>The Science of the Total Environment >Metabolomic profiles of the endangered St. Lawrence Estuary beluga population and associations with organohalogen contaminants
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Metabolomic profiles of the endangered St. Lawrence Estuary beluga population and associations with organohalogen contaminants

机译：濒临灭绝的圣劳伦斯河口白鲸种群的代谢组学谱以及与有机卤素污染物的关联

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The endangered beluga (Delphinapterus leucas) population residing in the St. Lawrence Estuary (SLE; Eastern Canada) is declining. The elevated tissue concentrations of a wide range of organohalogen contaminants might play a role in the non-recovery of this whale population. Organohalogens have been reported to impair the regulation of several metabolic products from cellular reactions in mammals such as amino acids and fatty acids. The objective of this study was to investigate a suite of organohalogens including polychlorinated biphenyls, organ-ochlorine pesticides, short-chain chlorinated paraffins (SCCPs), polybrominated diphenyl ethers, and selected emerging flame retardants in blubber (biopsy) collected from 40 SLE male belugas, and their relationships to skin concentrations of targeted metabolites (i.e., 21 amino acids, 22 biogenic amines, 18 fatty acids, and 17 energy metabolites). A cluster analysis based on metabolomic profiles distinguished two main subgroups of belugas in the upper and lower sector of their summer habitat in the SLE. These results indicate that ecological factors such as local prey availability and diet composition played a role in shaping the metabolite profiles of belugas. Moreover, SCCP concentrations in SLE male belugas correlated negatively with those of four unsaturated fatty acids (C16:lω7, C22:5ω3c1, C22:5ω3c2, and C22:6ω3), and positively with those of acetylornithine (biogenic amine). These findings suggest that biological functions such as lipid metabolism represent potential targets for organohalogens in this population, and further our understanding on potential health risks associated with elevated organohalogen exposure in cetaceans. Our results also underscore the necessity of considering ecological factors (e.g., diet and habitat use) in metabolomic studies.
机译：居住在圣劳伦斯河口（SLE;加拿大东部）中的濒危白鲸（Delphinapterus leucas）种群正在减少。各种有机卤素污染物的升高的组织浓度可能在该鲸类种群的未恢复中起作用。据报道，有机卤素会破坏哺乳动物细胞反应中几种代谢产物的调节，例如氨基酸和脂肪酸。这项研究的目的是研究一套有机卤素，包括多氯联苯，有机氯农药，短链氯化石蜡（SCCP），多溴联苯醚以及从40例SLE男性白鲸中收集的啤酒中的某些新兴阻燃剂（活检）。 ，以及它们与皮肤中目标代谢物（即21种氨基酸，22种生物胺，18种脂肪酸和17种能量代谢物）浓度之间的关系。基于代谢组学特征的聚类分析在SLE夏季生境的上，下部分区分了白鹭的两个主要亚组。这些结果表明，生态因素（例如当地猎物的可利用性和饮食结构）在塑造白鹭的代谢谱中发挥了作用。此外，SLE雄性白鲸中的SCCP浓度与四种不饱和脂肪酸（C16：1ω7，C22：5ω3c1，C22：5ω3c2和C22：6ω3）呈负相关，与乙酰鸟氨酸（生物胺）呈正相关。这些发现表明，诸如脂质代谢等生物学功能代表了该人群中有机卤素的潜在靶标，并且进一步使我们认识到与鲸类动物有机卤素暴露增加相关的潜在健康风险。我们的结果还强调了在代谢组学研究中必须考虑生态因素（例如饮食和栖息地使用）的必要性。

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