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首页> 外文期刊>The Science of the Total Environment >Suspect screening and target quantification of human pharmaceutical residues in the surface water of Wuhan, China, using UHPLC-Q-Orbitrap HRMS
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Suspect screening and target quantification of human pharmaceutical residues in the surface water of Wuhan, China, using UHPLC-Q-Orbitrap HRMS

机译：使用UHPLC-Q-Orbitrap HRMS对武汉市地表水中人药残留物进行可疑筛查和目标定量

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摘要

In this study we developed a systematic method for suspect screening and target quantification of the human pharmaceutical residues in water, via solid phase extraction (SPE) followed by liquid chromatography-high resolution mass spectrometry (LC-HRMS). We then proceeded to study the occurrences and distribution of the pharmaceuticals in the surface waters of Wuhan, China, by analyzing water samples from lakes, rivers and municipal sewage. Initially, 33 human pharmaceuticals were identified from East Lake without using purchasing standards. Of these, 29 were later confirmed by using standards, and quantified using the aforementioned SPE pretreatment method and LC-HRMS analysis in full MS scan mode. The 29 compounds included 8 antibiotics, 9 metabolites, and 12 miscellaneous pharmaceuticals. The highest proportions of pharmaceutical residues were detected downstream of the Yangtze River and in the lakes close to the central city. Metformin, cotinine, and trans-3-hydroxy cotinine, were frequently encountered in all the surface water samples. High concentrations (>120 ng/l) of caffeine, metformin, theobromine, and valsartan were detected in the surface water samples; the removal rates of these compounds in the municipal sewage treatment plant were also high. In contrast, although the concentrations of 4-AAA and metoprolol acid in the surface water were high, the removal rates of these residues in the sewage treatment plant were low.
机译：在这项研究中，我们开发了一种系统的方法，用于固相萃取（SPE），然后进行液相色谱-高分辨率质谱（LC-HRMS）进行水中人药残留物的可疑筛查和目标定量。然后，我们通过分析湖泊，河流和城市污水中的水样，研究了武汉市地表水中药物的发生和分布。最初，在不使用购买标准的情况下，从东湖发现了33种人类药品。其中有29个随后通过使用标准品进行了确认，并使用上述SPE预处理方法和全MS扫描模式下的LC-HRMS分析进行了定量。这29种化合物包括8种抗生素，9种代谢产物和12种其他药物。在长江下游和中心城市附近的湖泊中检出的药物残留量最高。在所有地表水样品中经常遇到二甲双胍，可替宁和反式3-羟基可替宁。在地表水样品中检测到高浓度（> 120 ng / l）的咖啡因，二甲双胍，可可碱和缬沙坦；这些化合物在市政污水处理厂中的去除率也很高。相反，尽管地表水中4-AAA和美托洛尔酸的浓度较高，但污水处理厂中这些残留物的去除率较低。

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  • 来源
    《The Science of the Total Environment》 |2018年第1期|828-837|共10页
  • 作者

    Muhammad Ali Asghar; Qingxin Zhu; Shutang Sun; Yuee Peng; Qin Shuai;

  • 作者单位

    State Key Laboratory of Biogeology and Environmental Geology, Faculty of Materials Science and Chemistry, China University of Geosciences;

    State Key Laboratory of Biogeology and Environmental Geology, Faculty of Materials Science and Chemistry, China University of Geosciences;

    State Key Laboratory of Biogeology and Environmental Geology, Faculty of Materials Science and Chemistry, China University of Geosciences;

    State Key Laboratory of Biogeology and Environmental Geology, Faculty of Materials Science and Chemistry, China University of Geosciences;

    State Key Laboratory of Biogeology and Environmental Geology, Faculty of Materials Science and Chemistry, China University of Geosciences;

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  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类
  • 关键词

    Human pharmaceuticals; Suspect screening; High resolution mass spectrometry; Q-Exactive; Surface water; Wuhan;

    机译：人用药品;可疑物筛查;高分辨率质谱;Q-Exactive;地表水;武汉;

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