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首页> 外文期刊>The Science of the Total Environment >Modelling the exposure to chemicals for risk assessment: a comprehensive library of multimedia and PBPK models for integration, prediction, uncertainty and sensitivity analysis - the MERLIN-Expo tool
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Modelling the exposure to chemicals for risk assessment: a comprehensive library of multimedia and PBPK models for integration, prediction, uncertainty and sensitivity analysis - the MERLIN-Expo tool

机译：为化学品暴露建模以进行风险评估：多媒体和PBPK模型的综合库，用于集成，预测，不确定性和敏感性分析-MERLIN-Expo工具

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摘要

MERLIN-Expo is a library of models that was developed in the frame of the FP7 EU project 4FUN in order to provide an integrated assessment tool for state-of-the-art exposure assessment for environment biota and humans, allowing the detection of scientific uncertainties at each step of the exposure process. This paper describes the main features of the MERLIN-Expo tool. The main challenges in exposure modelling that MERLIN-Expo has tackled are: (ⅰ) the integration of multimedia (MM) models simulating the fate of chemicals in environmental media, and of physiologically based pharmacokinetic (PBPK) models simulating the fate of chemicals in human body. MERUN-Expo thus allows the determination of internal effective chemical concentrations; (ⅱ) the incorporation of a set of functionalities for uncertainty/sensitivity analysis, from screening to variance-based approaches. The availability of such tools for uncertainty and sensitivity analysis aimed to facilitate the incorporation of such issues in future decision making; (ⅲ) the integration of human and wildlife biota targets with common fate modelling in the environment MERLIN-Expo is composed of a library of fate models dedicated to non biological receptor media (surface waters, soils, outdoor air), biological media of concern for humans (several cultivated crops, mammals, milk, fish), as well as wildlife biota (primary producers in rivers, invertebrates, fish) and humans. These models can be linked together to create flexible scenarios relevant for both human and wildlife biota exposure. Standardized documentation for each model and training material were prepared to support an accurate use of the tool by end-users. One of the objectives of the 4FUN project was also to increase the confidence in the applicability of the MERLIN-Expo tool through targeted realistic case studies. In particular, we aimed at demonstrating the feasibility of building complex realistic exposure scenarios and the accuracy of the modelling predictions through a comparison with actual measurements.
机译：MERLIN-Expo是在FP7欧盟项目4FUN框架下开发的模型库，目的是为环境生物和人类的最新接触评估提供一个集成的评估工具，从而能够检测科学不确定性在曝光过程的每个步骤。本文介绍了MERLIN-Expo工具的主要功能。 MERLIN-Expo应对暴露模型的主要挑战是：（ⅰ）集成模拟环境介质中化学物质命运的多媒体（MM）模型和模拟人体化学结构命运的生理学药代动力学（PBPK）模型身体。因此，MERUN-Expo可以确定内部有效化学浓度； （ⅱ）纳入了从筛查到基于方差的不确定性/敏感性分析的一组功能。此类工具可用于不确定性和敏感性分析，旨在促进将此类问题纳入未来的决策中； （ⅲ）将人类和野生动植物群目标与环境中常见的命运模型整合在一起MERLIN-Expo由专门针对非生物受体介质（地表水，土壤，室外空气），关注的生物介质的命运模型库组成人类（几种栽培作物，哺乳动物，牛奶，鱼类）以及野生生物群落（河流，无脊椎动物，鱼类的主要生产者）和人类。这些模型可以链接在一起，以创建与人类和野生动植物群落暴露相关的灵活方案。准备了每种模型和培训材料的标准化文档，以支持最终用户正确使用该工具。 4FUN项目的目标之一还在于通过有针对性的实际案例研究来提高对MERLIN-Expo工具适用性的信心。特别是，我们旨在通过与实际测量值进行比较来证明构建复杂的实际暴露场景的可行性以及建模预测的准确性。

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  • 来源
    《The Science of the Total Environment》 |2016年第15期|770-784|共15页
  • 作者

    P. Ciffroy; B. Alfonso; A. Altenpohl; Z. Banjac; J. Bierkens; C. Brochot; A. Critto; T. De Wilde; G. Fait; T. Fierens; J. Garratt; E. Giubilato; E. Grange; E. Johansson; A. Radomyski; K. Reschwann; N. Suciu; T. Tanaka; A. Tediosi; M. Van Holderbeke; F. Verdonck;

  • 作者单位

    Electricite de France (EDF) R&D, National Hydraulic and Environment Laboratory, 6 quai Watier, 78400 Chatou, France;

    Facilia AB, Gustavslundsvaegen 151C, 167 51 Bromma, Sweden;

    Austrian Standards Institute, Heinestr. 38, 1060 Vienna, Austria;

    Agencia Estatal Consejo Superior de Investigacions Cientificas CSIC, Barcelona, Spain;

    EUrelations AG, Technoparkstr. 1, 8005 Zurich, Switzerland;

    Flemish Institute for Technological Research (VITO), Human and Environmental Exposure and Risk Assessment, VITO - Health, Mol, Belgium;

    Institut National de l'Environnement Industriel et des Risques (INERIS), Unite Modeles pour l'Ecotoxicologie et la Toxicologie (METO), Parc ALATA BP2, 60550 Verneuil en Halatte, France;

    University Ca' Foscari Venice, Department of Environmental Sciences, Informatics and Statistics, Via Torino 155, 30172 Mestre-Venezia, Italy;

    Arche cvba, Liefkensstraat 35d, 9032 Gent (Wondelgem), Belgium;

    EUrelations AG, Technoparkstr. 1, 8005 Zurich, Switzerland;

    AIEFORIA srl, via Gramsci 22, 43036 Fidenza (PR), Italy;

    Institut National de l'Environnement Industriel et des Risques (INERIS), Unite Modeles pour l'Ecotoxicologie et la Toxicologie (METO), Parc ALATA BP2, 60550 Verneuil en Halatte, France;

    AIEFORIA srl, via Gramsci 22, 43036 Fidenza (PR), Italy;

    Facilia AB, Gustavslundsvaegen 151C, 167 51 Bromma, Sweden;

    Institut National de l'Environnement Industriel et des Risques (INERIS), Unite Modeles pour l'Ecotoxicologie et la Toxicologie (METO), Parc ALATA BP2, 60550 Verneuil en Halatte, France;

    Enviresearch Ltd., Herschel Building/Nanotechnology Centre, Newcastle University, Newcastle upon Tyne NE1 7RU, UK;

    Istituto di Chimica Agraria ed Ambientale, Universita Cattolica del Sacro Cuore, via Emilia Parmense 84, 29122, Piacenza, Italy;

    Electricite de France (EDF) R&D, National Hydraulic and Environment Laboratory, 6 quai Watier, 78400 Chatou, France;

    Arche cvba, Liefkensstraat 35d, 9032 Gent (Wondelgem), Belgium;

    EUrelations AG, Technoparkstr. 1, 8005 Zurich, Switzerland;

    University Ca' Foscari Venice, Department of Environmental Sciences, Informatics and Statistics, Via Torino 155, 30172 Mestre-Venezia, Italy;

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  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类
  • 关键词

    MERLIN-Expo; Exposure; Multimedia modelling; PBPK; Uncertainty;

    机译：MERLIN-Expo;接触;多媒体建模;PBPK;不确定;

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