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首页> 外文期刊>The Science of the Total Environment >Associations of gestational and early life exposures to ambient air pollution with childhood atopic eczema in Shanghai, China
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Associations of gestational and early life exposures to ambient air pollution with childhood atopic eczema in Shanghai, China

机译：中国上海市妊娠和早孕暴露于环境空气污染与儿童特应性湿疹的关系

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摘要

Whether ambient air pollution is associated with childhood atopic eczema is controversial In this paper, we selected 3358 preschool children who had not altered residences since pregnancy from a cross-sectional study during 2011-2012 in Shanghai, China, and obtained parent-reported data regarding childhood atopic eczema using an improved ISAAC questionnaire. We recorded daily concentrations of SO_2, NO_2, and PM_(10) throughout the child's lifetime (2006-2012), and calculated period-averaged concentrations for each district where the child lived to represent the child's exposure levels of these pollutants during different periods. In the multiple logistic regression analyses adjusted for potential confounders as well as for the other pollutants in the same periods, childhood atopic eczema was significantly associated with increments of NO_2 in the approximate interquartile range (20 μg/m~3) during gestational period (adjusted OR, 95% CI for eczema lifetime-ever: 1.80,1.29-2.49; for eczema in the year prior to the survey: 2.32,1.57-3.43) and during the first year of life (2.00,1.40-2.84; 2.16, 1.43-3.28). Exposure to elevated NO_2 in the first two years, three years and total lifetime, as well as exposure to mixtures containing NO_2 in each of these periods, were consistently associated with increased likelihood of childhood eczema. The highest odds ratios were found between exposure to a mixture of SO_2 and NO_2 during total lifetime (increment: 35 μg/m~3) and childhood eczema (adjusted OR, 95% CI: 2.80,1.75-4.48; 3.50,1.98-6.19). No significant associations were found between childhood eczema and ambient SO_2 and PM_(10) individually or in mixtures. This study indicates that gestational and lifetime exposures to ambient NO_2 are risk factors for atopic eczema in childhood Exposure to ambient SO_2 and PM_(10) may enhance the effect of NO_2 exposure on childhood eczema.
机译：环境空气污染是否与儿童特应性湿疹相关是否有争议在本文中，我们从2011-2012年间在中国上海进行的一项横断面研究中，选择了3358名学龄前儿童，这些孩子自怀孕以来并未改变居住地，并获得了父母报告的有关使用改良的ISAAC问卷调查儿童期特应性湿疹。我们记录了儿童整个一生（2006-2012年）中的SO_2，NO_2和PM_（10）的每日浓度，并计算了儿童所居住的每个地区的平均时期浓度，以代表儿童在不同时期的这些污染物的暴露水平。在针对潜在混杂因素以及同期的其他污染物进行的多元logistic回归分析中，在妊娠期（调整后），儿童特应性湿疹与大约四分位数范围（20μg/ m〜3）内NO_2的增加显着相关。或，终生湿疹的95％CI：1.80,1.29-2.49;调查前一年的湿疹：2.32,1.57-3.43）和生命的第一年（2.00,1.40-2.84; 2.16，1.43） -3.28）。在头两年，三年和总寿命中暴露于升高的NO_2中，以及在每个时期中暴露于含NO_2的混合物中，始终与儿童湿疹发生的可能性增加相关。在整个生命周期（增量：35μg/ m〜3）和儿童湿疹（调整后的OR，95％CI：2.80,1.75-4.48； 3.50，1.98-6.19）之间，接触SO_2和NO_2的混合物的最高比值比最高。 ）。在儿童湿疹与周围的SO_2和PM_（10）单独或混合中均未发现明显关联。这项研究表明，妊娠期和终生暴露于环境NO_2是儿童特应性湿疹的危险因素暴露于环境SO_2和PM_（10）可能会增强NO_2暴露对儿童湿疹的影响。

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  • 来源
    《The Science of the Total Environment》 |2016年第1期|34-42|共9页
  • 作者

    Wei Liu; Jiao Cai; Chen Huang; Yu Hu; Qingyan Fu; Zhijun Zou; Chanjuan Sun; Li Shen; Xueying Wang; Jun Pan; Yanmin Huang; Jing Chang; Zhuohui Zhao; Yuexia Sun; Jan Sundell;

  • 作者单位

    School of Environment and Architecture, University of Shanghai for Science and Technology (USST), Shanghai, China;

    School of Environment and Architecture, University of Shanghai for Science and Technology (USST), Shanghai, China;

    School of Environment and Architecture, University of Shanghai for Science and Technology (USST), Shanghai, China,Department of Building Environment and Energy Engineering, School of Environment and Architecture, University of Shanghai for Science and Technology, 516 Jungong Road, Yangpu District, Shanghai, China;

    Tongji Architectural Design (Croup) Company limited (TJAD), Shanghai China;

    Shanghai Environmental Monitoring Center (SEMC), Shanghai China;

    School of Environment and Architecture, University of Shanghai for Science and Technology (USST), Shanghai, China;

    School of Environment and Architecture, University of Shanghai for Science and Technology (USST), Shanghai, China;

    R&B Technology (Shanghai) Company Limited, Shanghai China;

    School of Environment and Architecture, University of Shanghai for Science and Technology (USST), Shanghai, China;

    Shanghai Environmental Monitoring Center (SEMC), Shanghai China;

    Shanghai Environmental Monitoring Center (SEMC), Shanghai China;

    School of Environment and Architecture, University of Shanghai for Science and Technology (USST), Shanghai, China,Department of Thermal Energy and Power Engineering, Shandong Jiaotong University, Jinan, China;

    Department of Environmental Health, School of Public Health, Fudan University, Shanghai China;

    School of Environmental Science and Engineering, Tianjin University, Tianjin, China;

    School of Environment and Architecture, University of Shanghai for Science and Technology (USST), Shanghai, China,Department of Building Science, Tsinghua University, Beijing, China;

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  • 原文格式 PDF
  • 正文语种 eng
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  • 关键词

    Ambient air pollution; Nitrogen dioxide; Atopic eczema; Preschool children; China;

    机译：环境空气污染;二氧化氮;特应性湿疹;学龄前儿童;中国;

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