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首页> 外文期刊>Science of the total environment >Polychlorinated dibenzo-p-dioxins and dibenzofurans and their association with cancer mortality among workers in one automobile foundry factory
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Polychlorinated dibenzo-p-dioxins and dibenzofurans and their association with cancer mortality among workers in one automobile foundry factory

机译：一家汽车铸造厂工人中的多氯二苯并对二恶英和二苯并呋喃及其与癌症死亡率的关系

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摘要

Polychlorinated dibenzo-p-dioxins and dibenzofurans (PCDD/Fs) have been reported as possible carcinogenic hazards to humans. However, epidemiological studies on their carcinogenic roles are limited. The current study was designed to determine the concentrations and characteristics of PCDD/Fs and evaluate their association with cancer mortality in exposed workers in one automobile foundry factory.PCDD/F levels in factory and surrounding environment were analyzed through air and settling dust sampling. The cancer mortalities among workers in this foundry factory were calculated using data from a cohort study. The results showed that the PCDD/F concentrations of air in workplace ranged 0.36-2.25 pg World Health Organization-Toxic Equivalent (WHO-TEQ) Nm~(-3) (average 1.01 pg WHO-TEQ Nm~(-3)), which were 1.16-7.26 times higher than those outside the factory. The PCDD/F concentrations of settling dust in the workplace ranged 3.34-18.64 pg WHO-TEQ g~(-1) (average 8.25 pg WHO-TEQ g~(-1)), which were lower than those just outside the factory (average 16.13 pg WHO-TEQ g~(-1)). Furthermore, a cohort study of workers in this factory with average follow-up of 24.52 years showed that cancer was the leading cause of death, with significant elevated mortality (standardized mortality ratio (SMR) = 1.70, 95% confidence interval (CI): 1.35-2.13) among workers, when compared with Chinese national mortality. The cancer mortality among front-line workers was increased significantly (adjusted relative risk (RR)=1.73, 95% Cl: 1.14-2.60), particularly among melting and casting workers, when compared with that among assistant workers. Our results indicated that there was a dose-response relationship between PCDD/F exposure and cancer mortality among foundry workers.
机译：据报道，多氯二苯并-对-二恶英和二苯并呋喃（PCDD / Fs）可能对人类致癌。但是，关于其致癌作用的流行病学研究有限。本研究旨在确定PCDD / Fs的浓度和特性，并评估其与一家汽车铸造厂裸露工人的癌症死亡率的相关性。通过空气和沉降粉尘取样分析工厂和周围环境中PCDD / F的水平。使用来自队列研究的数据计算了该铸造工厂工人的癌症死亡率。结果表明，工作场所空气中PCDD / F的浓度范围为0.36-2.25 pg世界卫生组织-有毒当量（WHO-TEQ）Nm〜（-3）（平均1.01 pg WHO-TEQ Nm〜（-3）），是工厂外的1.16-7.26倍。工作场所中尘埃的PCDD / F浓度范围为3.34-18.64 pg WHO-TEQ g〜（-1）（平均8.25 pg WHO-TEQ g〜（-1）），低于工厂外的浓度（平均16.13 pg WHO-TEQ g〜（-1））。此外，对该工厂工人进行的队列研究（平均随访时间为24.52年）表明，癌症是导致死亡的主要原因，死亡率显着升高（标准死亡率（SMR）= 1.70，95％置信区间（CI）： 1.35-2.13），与中国国民死亡率相比。与辅助工人相比，一线工人的癌症死亡率显着增加（调整后的相对风险（RR）= 1.73，95％Cl：1.14-2.60），尤其是在熔化和铸造工人中。我们的结果表明，铸造工人中PCDD / F暴露与癌症死亡率之间存在剂量反应关系。

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  • 来源
    《Science of the total environment》 |2013年第15期|104-111|共8页
  • 作者

    Lihua Wang; Shaofan Weng; Sheng Wen; Tingming Shi; Gangtao Sun; Yuyu Zeng; Cheng Qi; Weihong Chen;

  • 作者单位

    Department of Occupational & Environmental Health, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, 430030, China,Ministry of Education Key Lab of Environment and Health, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, 430030, China;

    Department of Occupational & Environmental Health, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, 430030, China,Ministry of Education Key Lab of Environment and Health, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, 430030, China;

    Hubei Provincial Center for Disease Control and Prevention, Wuhan, Hubei, 430074, China;

    Hubei Provincial Center for Disease Control and Prevention, Wuhan, Hubei, 430074, China;

    Department of Occupational & Environmental Health, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, 430030, China,Ministry of Education Key Lab of Environment and Health, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, 430030, China;

    Dongfeng Prevention and Treatment Center for Occupational Disease, Shiyan, Hubei, 442001, China;

    Dongfeng Prevention and Treatment Center for Occupational Disease, Shiyan, Hubei, 442001, China;

    Department of Occupational & Environmental Health, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, 430030, China,Ministry of Education Key Lab of Environment and Health, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, 430030, China;

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  • 正文语种 eng
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  • 关键词

    PCDD/Fs; automobile foundry; air; dust; cancer mortality;

    机译：PCDD / Fs;汽车铸造厂空气;灰尘;癌症死亡率;

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