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Assessment of health risks with reference to oxidative stress and DNA damage in chromium exposed population

机译：评估铬暴露人群的氧化应激和DNA损伤对健康的危害

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摘要

Trivalent chromium [Cr(III)] is widely used in tanning industrial processes. The population living in tanning industrial area is continuously exposed to Cr(IH) which appears to be associated with both acute and chronic health problems. Therefore, the aim of this study was to evaluate the health risk with special reference to oxidative stress parameters (malondialdehyde - MDA, glutathione-GSH, and superoxide dismutase -SOD) and DNA damage in 100 Cr-exposed and 100 unexposed populations. The total blood Cr level, SOD level, MDA level and DNA damage were significantly (p＜0.05) higher and GSH level was significantly (p＜0.05) lower in exposed group as compared to the unexposed group. The altered oxidative stress parameters and DNA damage were found to be slightly higher in female population of both groups. In simple and multiple correlation analyses (adjusted with potential confounders), blood Cr level showed negative significant correlation with GSH level and positive significant correlation with level of MDA, SOD and DNA damage in both groups. The overall prevalence of morbidity was found to be significantly (p＜0.05) higher in the exposed group as compared to the unexposed group. In the exposed group, the prevalence of respiratory illness is highest, followed by diabetes, gastrointestinal tract problems and dermal problems respectively. Our results concluded that the Cr(Ⅲ) exposed population is at high risk for health hazards and the female population is slightly more susceptible to Cr(Ⅲ) exposure.
机译：三价铬[Cr（III）]被广泛用于制革工业过程中。鞣制工业区中的居民不断暴露于Cr（IH），这似乎与急性和慢性健康问题有关。因此，本研究的目的是评估氧化应激参数（丙二醛-MDA，谷胱甘肽-GSH和超氧化物歧化酶-SOD）和100 Cr暴露人群和100个未暴露人群的DNA损伤对健康的危害。与未暴露组相比，暴露组的总血Cr水平，SOD水平，MDA水平和DNA损伤显着升高（p ＜0.05），GSH水平显着降低（p ＜0.05）。发现两组女性人群中氧化应激参数和DNA损伤的改变均略高。在简单和多重相关分析（经潜在混杂因素调整）中，两组血Cr含量均与GSH水平呈负显着相关，与MDA，SOD和DNA损伤水平呈正相关。与未暴露组相比，暴露组的总患病率显着高（p ＜0.05）。在暴露人群中，呼吸系统疾病的患病率最高，其次是糖尿病，胃肠道疾病和皮肤病。我们的结果得出结论，暴露于Cr（Ⅲ）的人群有健康危害的高风险，而女性人群则更容易受到Cr（Ⅲ）的暴露。

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  • 来源
    《The Science of the Total Environment》 |2012年第15期|p.68-74|共7页
  • 作者

    Faizan Haider Khan; Khushboo Ambreen; Ghizal Fatima; Sudhir Kumar;

  • 作者单位

    Molecular & Human Genetics Laboratory, Department of Zoology, University of Lucknow, Lucknow-226007, India;

    Molecular & Human Genetics Laboratory, Department of Zoology, University of Lucknow, Lucknow-226007, India;

    Department of Biochemistry, C.S.M. Medical University, Lucknow-226003, India;

    Molecular & Human Genetics Laboratory, Department of Zoology, University of Lucknow, Lucknow-226007, India;

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  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类
  • 关键词

    chromium; oxidative stress; DNA damage; morbidity;

    机译：铬;氧化应激DNA损伤;发病率;

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