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首页> 外文期刊>The Science of the Total Environment >Biomonitoring of children exposure to urban pollution and environmental tobacco smoke with hair analysis - A pilot study on children living in Paris and Yeu Island, France
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Biomonitoring of children exposure to urban pollution and environmental tobacco smoke with hair analysis - A pilot study on children living in Paris and Yeu Island, France

机译：儿童接触城市污染和环境烟草烟雾的生物化与头发分析 - 法国巴黎儿童的试验研究

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The impact of pollution on children's health has been increasingly pointed out in numerous studies which emphasized their increased vulnerability compared to adults. This pilot study investigated the relevance of hair analysis for the assessment of children exposure to pollution and to environmental tobacco smoke (ETS). The methodology based on GC-MS/MS and LC-MS/MS, is the first one to investigate simultaneously parent PAH (n = 15), PAH metabolites (n = 56), nicotine and cotinine in a biological matrix. The method was applied to hair samples collected from 25 children, aged from 2 to 11 years, living in Paris, France, selected as densely populated area with urban pollution including vehicle exhausts, and Yeu Island, a French island in the Atlantic ocean, selected as control area with low population density and no fuel powered vehicles. Nicotine and cotinine were detected in all the samples at concentrations up to 2275 pg/mg and 110 pg/mg respectively, suggesting exposure to ETS in the two areas. 10 parent PAH and 10 metabolites were detected in 100% and in 90% of the samples respectively. Eight of these biomarkers presented a significantly higher concentration in children from Paris than from Yeu Island. The results suggest association between PAH exposure and estimated time of exposure to vehicle exhaust as well as higher exposure to both PAH and ETS in the youngest children. Although these findings need to be confirmed on wider populations, the results obtained in this pilot study strongly support the relevance of hair analysis for the biomonitoring of children exposure to urban pollution and ETS. (c) 2019 Elsevier B.V. All rights reserved.
机译：在许多研究中，污染对儿童健康的影响越来越多地指出，与成年人相比，他们强调他们增加的脆弱性。该试点研究调查了头发分析对儿童暴露于污染和环境烟草烟雾（ETS）的相关性的相关性。基于GC-MS / MS和LC-MS / MS的方法是第一个在生物基质中同时探讨亲本PAH（n = 15），尼古丁和尼古丁的肝素PAH（n = 15）。将该方法应用于从25名儿童收集的毛发样品，从2至11年龄，在法国巴黎，被选中为浓密的人口污染，包括车辆排气，以及大西洋的法国岛屿，选择作为具有低人口密度和燃料动力车辆的控制区域。在所有样品中以高达2275pg / mg和110pg / mg的所有样品中检测到尼古丁和胞苷，表明在两个区域中暴露于ETS。分别以100％和> 90％的样品中检测到10个亲本PAH和10代谢物。这些生物标志物中的八个在巴黎的儿童中呈现出明显更高的浓度，而不是来自yeu岛。结果表明PAH暴露与估计在最小儿童中的估计暴露于车辆排气的时间以及更高的儿童接触。虽然需要在更广泛的人群中确认这些调查结果，但该试点研究中获得的结果强烈支持头发分析对城市污染和ETS的生物化的头发分析的相关性。 （c）2019 Elsevier B.v.保留所有权利。

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