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首页> 外文期刊>Science of the total environment >A study of metal concentrations and metallothionein binding capacity in liver, kidney and brain tissues of three Arctic seal species
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A study of metal concentrations and metallothionein binding capacity in liver, kidney and brain tissues of three Arctic seal species

机译：三种北极海豹物种肝脏，肾脏和脑组织中金属浓度和金属硫蛋白结合能力的研究

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摘要

Arctic seals are known to accumulate relatively high concentrations of potential toxic heavy metals in their vital organs, such as livers and kidneys, as well as in their central nervous system. We therefore decided to determine whether mercury, copper, cadmium and zinc levels in liver, kidney and brain tissues of three Arctic seal species were associated with the intracellular metal-binding protein metallothionein (MT) as a sign of toxic exposure. Samples from four ringed (Phoca hispida), five harp (P. groenlandica) and five hooded (Cystophora cristata) seals taken during field trips to Central West Greenland (Godhavn) and the Barents Sea in the spring of 1999 were used for the present study. In all three seal species concentrations of mercury, zinc and copper were highest in the liver, except for cadmium which was highest in the kidneys. Metal concentrations increased significantly in the order: ringed seal < harp seal < hooded seal for both kidney and liver tissues. MT concentrations were highest in the kidneys and the concentrations increased in the order: ringed seal < hooded seal < harp seal. MT metal-binding capacity was highest in the kidneys for all three species and increased in the same order: ringed seals (2-10%)
机译：已知北极海豹在其重要器官（例如肝脏和肾脏）以及中枢神经系统中会积累相对较高浓度的潜在有毒重金属。因此，我们决定确定三种北极海豹物种的肝脏，肾脏和脑组织中的汞，铜，镉和锌水平是否与细胞内金属结合蛋白金属硫蛋白（MT）相关联，作为有毒暴露的迹象。本研究使用了在1999年春季实地考察西格陵兰（Godhavn）和巴伦支海的四只环斑海豹（Phoca hispida），五只竖琴（P. groenlandica）和五只带帽海豹（Cystophora cristata）的样本。 。在所有三种海豹种类中，汞，锌和铜的浓度在肝脏中最高，但镉在肾脏中最高。金属浓度按以下顺序显着增加：环形的海豹<竖琴海豹<肾脏和肝脏组织的带帽海豹。肾脏中的MT浓度最高，并且浓度依次升高：环状海豹<带帽海豹<竖琴海豹。在所有三个物种中，MT的金属结合能力在肾脏中最高，并且以相同的顺序增加：环状海豹（2-10％）<带帽海豹（8-15％）<竖琴海豹（27-63％）。因此，我们建议在重金属的亚细胞处理中存在物种特异性差异，这表明敏感性和健康影响方面的差异。但是，为了测试金属浓度和MT上调之间的关系，需要更大的样本量，以便确定哪种金属最重要，并阐明MT的结合能力是否足以保护组织（即肾脏）免受金属中毒。具有结合能力的MT可能是环境暴露于金属及其在北极的潜在毒性的有用标志。

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  • 来源
    《Science of the total environment》 |2009年第24期|6166-6172|共7页
  • 作者

    Christian Sonne; Ole Aspholm; Rune Dietz; Steen Andersen; Marc H.G. Berntssen; Ketil Hylland;

  • 作者单位

    Section for Contaminants, Effects and Marine Mammals, Department of Arctic Environment, National Environmental Research Institute, Aarhus University, Frederiksborgvej 399, P.O. Box 358, DK-4000 Roskilde, Denmark;

    NIVA, CIENS, Gaustadalleen 21, N-0349 Oslo, Norway DNV, Veritasveien 1, N-1322 Hovik, Norway;

    Section for Contaminants, Effects and Marine Mammals, Department of Arctic Environment, National Environmental Research Institute, Aarhus University, Frederiksborgvej 399, P.O. Box 358, DK-4000 Roskilde, Denmark;

    HuntersScience.com, Vingaards Alle 51, DK-2900 Hellerup, Denmark;

    NIFES, PB 2029, Nordnes, N-5817, Bergen, Norway;

    NIVA, CIENS, Gaustadalleen 21, N-0349 Oslo, Norway Department of Biology, University of Oslo, P.O.Box 1066, Blindem, N-0316 Oslo, Norway;

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  • 关键词

    arctic; brain; cadmium; copper; liver; kidney; mercury; metallothionein; MT; seal; zinc;

    机译：北极;脑;镉;铜;肝;肾;汞;金属硫蛋白公吨;密封;锌;

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