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首页> 外文期刊>Science >CRMP2-binding compound, edonerpic maleate, accelerates motor function recovery from brain damage
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CRMP2-binding compound, edonerpic maleate, accelerates motor function recovery from brain damage

机译：结合CRMP2的化合物马来酸埃德能比，可促进脑损伤后运动功能的恢复

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摘要

Brain damage such as stroke is a devastating neurological condition that may severely compromise patient quality of life. No effective medication-mediated intervention to accelerate rehabilitation has been established. We found that a small compound, edonerpic maleate, facilitated experience-driven synaptic glutamate AMPA (alpha-amino-3-hydroxy-5-methyl-4-isoxazole-propionic-acid) receptor delivery and resulted in the acceleration of motor function recovery after motor cortex cryoinjury in mice in a training-dependent manner through cortical reorganization. Edonerpic bound to collapsin-response-mediator-protein 2 (CRMP2) and failed to augment recovery in CRMP2-deficient mice. Edonerpic maleate enhanced motor function recovery from internal capsule hemorrhage in nonhuman primates. Thus, edonerpic maleate, a neural plasticity enhancer, could be a clinically potent small compound with which to accelerate rehabilitation after brain damage.
机译：脑损伤（如中风）是一种破坏性神经病，可能会严重损害患者的生活质量。尚未建立有效的药物介导干预措施来加速康复。我们发现一种小的化合物马来酸edonerpic，促进了经验驱动的突触谷氨酸AMPA（α-氨基-3-羟基-5-甲基-4-异恶唑-丙酸）受体传递，并导致运动功能恢复后加速通过皮层重组以依赖于训练的方式使小鼠运动皮层冷冻损伤。 Edonerpic绑定到胶原蛋白反应介质蛋白2（CRMP2），并未能增加CRMP2缺陷小鼠的恢复。马来酸烯丙二酯增强非人灵长类动物从内膜出血中恢复运动功能的能力。因此，马来酸edonerpic是一种神经可塑性增强剂，可能是一种临床上有效的小化合物，可用来加速脑损伤后的康复。

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  • 来源
    《Science》 |2018年第6384期|50-57|共8页
  • 作者

    Abe Hiroki; Jitsuki Susumu; Nakajima Waki; Murata Yumi; Jitsuki-Takahashi Aoi; Katsuno Yuki; Tada Hirobumi; Sano Akane; Suyama Kumiko; Mochizuki Nobuyuki; Komori Takashi; Masuyama Hitoshi; Okuda Tomohiro; Goshima Yoshio; Higo Noriyuki; Takahashi Takuya;

  • 作者单位

    Yokohama City Univ, Grad Sch Med, Dept Physiol, Yokohama, Kanagawa 2360004, Japan;

    Yokohama City Univ, Grad Sch Med, Dept Physiol, Yokohama, Kanagawa 2360004, Japan;

    Yokohama City Univ, Grad Sch Med, Dept Physiol, Yokohama, Kanagawa 2360004, Japan;

    Natl Inst Adv Ind Sci & Technol, Human Informat Res Inst, Tsukuba 3058568, Japan;

    Yokohama City Univ, Grad Sch Med, Dept Physiol, Yokohama, Kanagawa 2360004, Japan;

    Yokohama City Univ, Grad Sch Med, Dept Physiol, Yokohama, Kanagawa 2360004, Japan;

    Yokohama City Univ, Grad Sch Med, Dept Physiol, Yokohama, Kanagawa 2360004, Japan;

    Yokohama City Univ, Grad Sch Med, Dept Physiol, Yokohama, Kanagawa 2360004, Japan;

    Yokohama City Univ, Grad Sch Med, Dept Physiol, Yokohama, Kanagawa 2360004, Japan;

    Yokohama City Univ, Grad Sch Med, Dept Physiol, Yokohama, Kanagawa 2360004, Japan;

    Yokohama City Univ, Grad Sch Med, Dept Physiol, Yokohama, Kanagawa 2360004, Japan;

    Yokohama City Univ, Grad Sch Med, Dept Physiol, Yokohama, Kanagawa 2360004, Japan;

    Toyama Chem Co, Tokyo 1600023, Japan;

    Yokohama City Univ, Grad Sch Med, Dept Mol Pharmacol & Neurobiol, Yokohama, Kanagawa 2360004, Japan;

    Natl Inst Adv Ind Sci & Technol, Human Informat Res Inst, Tsukuba 3058568, Japan;

    Yokohama City Univ, Grad Sch Med, Dept Physiol, Yokohama, Kanagawa 2360004, Japan;

  • 收录信息 美国《科学引文索引》(SCI);美国《工程索引》(EI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
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