The cancer stem cell hypothesis1 was and remains so widely accepted because it appears to make so much sense. Personally, I was very excited by the theory when it first broke, as it provides such a tremendous starting point for tackling cancer at its roots and also helps to explain remission and relapse of disease. It has come with great disappointment that the theory appears flawed for many different cancer types. What a shame that great hypotheses do not always hold true!
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