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Unlocking the clock

机译:解锁时钟

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In October 2004, just as the clocks were changing in Illinois, the focus of Kevin Keegan's graduate work on cir-cadian clocks was changing, too. Keegan, a PhD student at Northwestern University in Evanston, 111., was developing computer code to analyze preliminary data coming out of a microarray study to find Drosophila circadian rhythm genes. "On a lark," he decided to test his code on some previous circadian gene-hunting studies. Together with his supervisor, Ravi Allada, Keegan ran the data from those five reports through his pilot algorithm, and out popped a complete surprise: many new genes that the reports had missed and had never been implicated before in daily timing. "I totally didn't expect to find a number of novel genes," he says. Quickly, the original "side project" of sifting through the existing data to find the best set of circadian genes became a top priority.
机译:2004年10月,正当伊利诺伊州的时钟发生变化时,凯文·基根(Kevin Keegan)的研究生工作重点也转移了。 Keegan是西北大学埃文斯顿分校(111.)的博士生,他正在开发计算机代码,以分析微阵列研究中发现果蝇昼夜节律基因的初步数据。他决定“在百灵鸟中”对先前的生物钟基因研究进行测试。 Keegan与他的主管Ravi Allada一起通过他的试验算法运行了这五份报告中的数据,并突然弹出一个令人惊讶的发现:报告遗漏了许多新基因,这些新基因在日常工作中从未涉及过。他说:“我完全没想到会找到许多新颖的基因。”很快,筛选现有数据以找到最佳昼夜节律基因的原始“副项目”成为当务之急。

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  • 来源
    《Scientist》 |2008年第6期|27|共1页
  • 作者

    Elie Dolgin;

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