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25 Years Ago in Immunology

机译:25年前的免疫学

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In the early 1980s, a few researchers began to speculate that a retrovirus was the cause of the mysterious disease known as AIDS. In this essay, Luc Montagnier, then the director of the virology department at the Pasteur Institute in Paris, and his colleagues describe the experiments proving that a retrovirus is the causative agent. The group isolated a novel retrovirus from the lymph node of an AIDS patient and showed that it produced a decline of lymphocyte proliferation. Their paper was cited 835 times in the three years following its publication in 1983, according to ISI, and more than 4,300 times in total. A year later, Robert Gallo conclusively identified HIV as the cause of AIDS. He and Montagnier spent years fighting over credit for the discovery, and in 1986 both received the Lasker Award for their AIDS research. Montagnier founded the World Foundation for AIDS Research and Prevention in partnership with UNESCO in 1993.
机译:在1980年代初期,一些研究人员开始推测逆转录病毒是导致这种称为AIDS的神秘疾病的原因。在这篇文章中,时任巴黎巴斯德研究所病毒学系主任的卢克·蒙塔尼尔(Luc Montagnier)和他的同事描述了证明逆转录病毒是病原体的实验。该小组从一名艾滋病患者的淋巴结中分离出了一种新型的逆转录病毒,并表明它导致淋巴细胞增殖的下降。根据ISI,他们的论文在1983年发表后的三年中被引用了835次,总计被引用了4,300多次。一年后,罗伯特·加洛(Robert Gallo)最终确定了艾滋病毒是艾滋病的病因。他和蒙塔格尼尔花了多年的时间才为这项发现争取荣誉,并于1986年都因其艾滋病研究获得了拉斯克奖。 Montagnier于1993年与教科文组织合作建立了世界艾滋病研究与预防基金会。

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