First Actin-binding Protein, circa 1975

Megan Scudellari

首页> 外文期刊>Scientist >First Actin-binding Protein, circa 1975

【24h】

First Actin-binding Protein, circa 1975

机译：第一个肌动蛋白结合蛋白，1975年左右

获取原文

获取原文并翻译 | 示例

掌桥外文数据库（机构版） >>

开具论文收录证明 >>

文献代查 >>

页面导航

摘要
著录项
相似文献
相关主题

摘要

It was 1975, and Thomas Stossel and John Hartwig were baffled by the "ugly precipitate" in the bottom of their test tube. Eager young biologists, the Harvard friends had set out to solve the mystery of how cells crawl. The field of cell movement was abuzz with the revelation that non-muscle cells contained actin and myosin, but no one understood the mechanism regulating those cytoskeleton proteins. Many researchers believed the protein contractions were controlled by calcium, similar to muscle cells. Stossel and Hartwig decided to purify myosin from white blood cells as a way to find the "magic calcium stuff" recalls Stossel. Instead, their test tube was filled with some "contaminant": A high molecular weight polymer they would soon identify as the first actin-binding protein, later called filamin A.

机译：1975年，托马斯·斯托塞尔（Thomas Stossel）和约翰·哈特维格（John Hartwig）被试管底部的“丑陋沉淀”所困扰。哈佛大学的朋友们都是年轻的生物学家，他们年轻而热切，他们着手解决细胞爬行的奥秘。揭示非肌肉细胞中含有肌动蛋白和肌球蛋白的信息引起了细胞运动领域的广泛讨论，但没人能理解调节这些细胞骨架蛋白的机制。许多研究人员认为，蛋白质的收缩受钙的控制，类似于肌肉细胞。 Stossel和Hartwig决定从白细胞中纯化肌球蛋白，以此作为发现“神奇钙质”的一种方式。取而代之的是，他们的试管中充满了一些“污染物”：一种高分子量聚合物，他们很快将其鉴定为第一个肌动蛋白结合蛋白，后来称为丝素A。

著录项

来源
《Scientist》 |2008年第9期|84|共1页
作者
Megan Scudellari;
展开▼
作者单位

展开▼
收录信息
原文格式 PDF
正文语种 eng
中图分类
关键词

相似文献

外文文献
中文文献
专利

1. Actin-binding proteins as molecular targets to modulate hepatic stellate cell proliferation. Focus on "MARCKS actin-binding capacity mediates actin filament assembly during mitosis in human hepatic stellate cells" [J] . Gemma Odena1 Ramon Bataller American Journal of Physiology . 2012,第2aPta1期

机译：肌动蛋白结合蛋白作为调节肝星状细胞增殖的分子靶标。专注于“ MARCKS肌动蛋白结合能力在人肝星状细胞的有丝分裂过程中介导肌动蛋白丝组装”
2. Recovery from DNA Damage-induced G2 Arrest Requires Actin-binding Protein Filamin-A/Actin-binding Protein 280* [J] . Xiangbing Meng, Yuan Yuan, Adrian Maestas, The Journal of biological chemistry . 2004,第7期

机译：从DNA损伤诱导的G2逮捕中恢复需要肌动蛋白结合蛋白Filamin-A /肌动蛋白结合蛋白280 *
3. Tropomyosin distinguishes between the two actin-binding sites of villin and affects actin-binding properties of other brush border proteins. [J] . D R Burgess, K O Broschat, J M Hayden Journal of cell biology . 1987,第1期

机译：Tropomyosin区分了villin的两个肌动蛋白结合位点，并影响其他刷缘蛋白的肌动蛋白结合特性。
4. EFFECTS OF MECHANICAL STRAIN ON STRUCTURAL AND ACTIN-BINDING PROTEINS IN NEUROBLASTS [C] . Szu-Yuan Chou, Chao-Min Cheng, Yi-Wen Lin, ASME summer bioengineering conference;SBC2009 . 2009

机译：机械应变对神经母细胞结构和肌动蛋白结合蛋白的影响
5. Structural Studies of Actin-Binding Proteins Involved in Actin Dynamics, Organization, and Force Sensing [D] . Huehn, Andrew Robert. 2020

机译：参与肌动蛋白动态，组织和力传感的肌动蛋白结合蛋白的结构研究
6. Tropomyosin distinguishes between the two actin-binding sites of villin and affects actin-binding properties of other brush border proteins [O] . 1987

机译：Tropomyosin区分villin的两个肌动蛋白结合位点并影响其他刷缘蛋白的肌动蛋白结合特性
7. Tropomyosin distinguishes between the two actin-binding sites of villin and affects actin-binding properties of other brush border proteins [O] . 1987

机译：Tropomyosin区分villin的两个肌动蛋白结合位点，并影响其他刷缘蛋白的肌动蛋白结合特性

First Actin-binding Protein, circa 1975

摘要

著录项

相似文献

相关主题

期刊订阅