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Spray Deposited ZnO Nanograins for Enzyme-Free Detection of Sarcosine

机译:喷雾沉积的ZnO纳米注酶免测肌肉氨基氨基

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摘要

Sarcosine is one of the known small molecule biomarkers to detect prostate cancereffectively. In the present work, we presented a very simple procedure and low-costnon-enzymatic method for the detection of Sarcosine. Zinc oxide (ZnO) nanoparticleswere successfully synthesized, characterized and elucidated the morphologyon the Indium tin oxide (ITO) surface, which showed uniform arrangement with aspherical shape. The ITO working electrode modified with ZnO exhibits better analyticalcharacteristics for Sarcosine sensing with a linear range between 5 and 100nM. The limit of detection was found to be low (7.5 nM) with excellent sensitivityand possess quick response time. Due to its high specificity and repeatability, theITO/ZnO working electrode does not interfere with the other amino acids in the realsamples.
机译:肌氨酸是已知的小分子生物标志物之一,用于检测前列腺癌 有效地。 在目前的工作中,我们提出了一个非常简单的程序和低成本 用于检测肌氨酸的非酶促方法。 氧化锌(ZnO)纳米粒子 成功地合成,特征和阐明了形态学 在氧化铟锡(ITO)表面上,其显示均匀的布置 球形。 用ZnO改性的ITO工作电极表现出更好的分析 用5到100之间的线性范围进行肌肉感测的特征 nm。 发现检测限为低(7.5nm),具有优异的敏感性 并具有快速的响应时间。 由于其高特异性和可重复性, ITO / ZnO工作电极不会干扰真实的其他氨基酸 样品。

著录项

  • 来源
    《Sensing and imaging》 |2021年第1期|46.1-46.16|共16页
  • 作者单位

    Center for Nanotechnology and Advanced Biomaterials SASTRA Deemed to be University Thanjavur Tamilnadu 613401 India;

    Functional Nanomaterials lab @School of Electrical & Electronics Engineering SASTRADeemed to be University Thanjavur Tamilnadu 613401 India;

    Functional Nanomaterials lab @School of Electrical & Electronics Engineering SASTRADeemed to be University Thanjavur Tamilnadu 613401 India;

    Functional Nanomaterials lab @School of Electrical & Electronics Engineering SASTRADeemed to be University Thanjavur Tamilnadu 613401 India;

    Functional Nanomaterials lab @School of Electrical & Electronics Engineering SASTRADeemed to be University Thanjavur Tamilnadu 613401 India;

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  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类
  • 关键词

    Sarcosine; ITO/ZnO working electrode; Cyclic voltammetry; Prostate cancer;

    机译:sarcosine;ITO / ZnO工作电极;循环伏安;前列腺癌;

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