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首页> 外文期刊>Sensors and Actuators >Colorimetric determination of nabumetone based on localized surface plasmon resonance of functionalized gold nanoparticles as a chemical sensor
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Colorimetric determination of nabumetone based on localized surface plasmon resonance of functionalized gold nanoparticles as a chemical sensor

机译：基于功能化金纳米颗粒作为化学传感器的局部表面等离子体共振比色法测定萘丁美酮

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摘要

A highly selective and sensitive colorimetric sensor for the determination of nabumetone (NAB) based on the aggregation of the thiolated p-cyclodextrin (Tβ-CD) functionalized gold nanoparticles (Au-NPs) with NAB in the presence of polyvinylpyrrolidone (PVP) was developed. Thiolated p-cyclodextrin bonds to the surface of Au-NPs and forms a complex with NAB. The presence of PVP changed the NAB:Tβ-CD complex to the NAB:(Tβ-CD)_2:PVP ternary complex which resulted in the aggregation of the Au-NPs. As a result of this aggregation, the localized surface plasmon resonance (LSPR) band of Au-NPs around 520 nm decreased and a new red shifted band at 650 nm appeared which gradually increased with an increase in the NAB concentration. Under the optimized conditions, the calibration curve derived from the ratio of absorbance intensity at 650 nm to the original wavelength of 520 nm against NAB concentration was linear in the concentration range of 1-120 μgL~(-1). The limits of detection (LOD) and quantification (LOQ) were 0.2 and 0.7μgL~(-1), respectively. The relative standard deviation at 20μgL~(-1) of NAB was found to be 3.1%. The selectivity of the method was demonstrated through the analysis of the synthetic samples containing the major interference compound reported in the literature. Finally, the method was successfully applied to the determination of NAB in pharmaceutical, urine and wastewater samples.
机译：在聚乙烯吡咯烷酮（PVP）存在下，开发了一种基于NAB的巯基化对环糊精（Tβ-CD）功能化的金纳米颗粒（Au-NPs）聚集体的萘丁酮（NAB）测定方法的高选择性和灵敏传感器。 。硫醇化的对环糊精键合到Au-NPs的表面，并与NAB形成复合物。 PVP的存在将NAB：Tβ-CD复合物变为NAB：（Tβ-CD）_2：PVP三元复合物，这导致Au-NP的聚集。这种聚集的结果是，在520nm附近的Au-NPs的局部表面等离子体激元共振（LSPR）带减少，并且在650nm处出现新的红移带，其随着NAB浓度的增加而逐渐增加。在最佳条件下，从650nm的吸光度强度到520nm的原始波长与NAB浓度的比值得出的校准曲线在1-120μgL〜（-1）的浓度范围内是线性的。检测限（LOD）和定量限（LOQ）分别为0.2和0.7μgL〜（-1）。发现NAB在20μgL〜（-1）时的相对标准偏差为3.1％。该方法的选择性通过分析包含文献中报道的主要干扰化合物的合成样品来证明。最终，该方法成功地用于药物，尿液和废水样品中NAB的测定。

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