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首页> 外文期刊>Sensors and Actuators >Fabrication of whole-thermoplastic normally closed microvalve, micro check valve, and micropump
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Fabrication of whole-thermoplastic normally closed microvalve, micro check valve, and micropump

机译:全热塑性常闭微型阀,微型止回阀和微型泵的制造

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摘要

There is a critical need to develop fabrication methods for rapid and cost-effective prototyping of thermoplastics-based microfluidics in academic research laboratories. This paper presents a method for the fabrication of whole-thermoplastic microfluidic functional elements, including a pneumatic (gas-actuated) normally closed microvalve, a micro-check valve, and a pneumatic dual-phase micropump. All devices were made from thermoplastic polyurethane (TPU) and poly(methyl methacrylate) (PMMA). The fabrication process consisted of only laser micromachining and thermal fusion bonding without need to perform any particular chemical treatment or use a master mold. These features enable the widespread adaptation of this method in academic research settings. Characterizations revealed that the fabricated normally closed microvalve could stop liquid flows at pressures lower than 2 psi in its passive operation mode where no pressure was used for valve actuation. The check valve could block liquid flows with liquid pressures of up to 30 psi in its reverse mode of operation while it could allow liquid to pass through in its forward mode. In addition, the micropump, which consisted of two check valves and a pneumatic uni-diaphragm displacement chamber, could pump liquid at an average flow rate of 87.6 ± 5.0 μL/min using an actuation frequency and pressure of 1 Hz and ±5 psi, respectively. Taken together, the developed low-cost whole-thermoplastic microfluidic functional elements could be employed for the fabrication of various lab-on-a-chip applications.
机译:迫切需要在学术研究实验室中开发制造方法,以快速,经济高效地对基于热塑性塑料的微流体进行原型制作。本文提出了一种全热塑性微流体功能元件的制造方法,包括气动(气控)常闭微型阀,微型止回阀和气动双相微型泵。所有设备均由热塑性聚氨酯(TPU)和聚甲基丙烯酸甲酯(PMMA)制成。制造过程仅包括激光微加工和热熔合,而无需执行任何特定的化学处理或使用母模。这些功能使该方法可以在学术研究环境中广泛使用。特征表明,在不使用任何压力进行阀门致动的被动运行模式下,所制造的常闭微型阀可以在低于2 psi的压力下阻止液体流动。止回阀在其反向操作模式下可阻止液体压力高达30 psi的液体流动,而在其前进模式下则可允许液体通过。此外,由两个止回阀和一个气动单隔膜排量腔组成的微型泵可以在1 Hz和±5 psi的驱动频率和压力下以87.6±5.0μL/ min的平均流量泵送液体,分别。综上所述,开发的低成本全热塑性微流体功能元件可用于制造各种芯片实验室应用。

著录项

  • 来源
    《Sensors and Actuators》 |2018年第6期|625-636|共12页
  • 作者单位

    Division of Engineering in Medicine, Department of Medicine, Brigham and Women’s Hospital, Harvard Medical School,Harvard-MIT Division of Health Sciences and Technology, Massachusetts Institute of Technology,Department of Electrical Engineering, Sahand University of Technology;

    Division of Engineering in Medicine, Department of Medicine, Brigham and Women’s Hospital, Harvard Medical School,Harvard-MIT Division of Health Sciences and Technology, Massachusetts Institute of Technology,Orthopedic Research Center, Mashhad University of Medical Sciences,Clinical Research Unit, School of Medicine, Mashhad University of Medical Sciences;

    Department of Electrical Engineering, Sahand University of Technology;

    Department of Electrical Engineering, Sahand University of Technology;

    Division of Engineering in Medicine, Department of Medicine, Brigham and Women’s Hospital, Harvard Medical School,Harvard-MIT Division of Health Sciences and Technology, Massachusetts Institute of Technology,Wyss Institute for Biologically Inspired Engineering, Harvard University,Center for Minimally Invasive Therapeutics (C-MIT), University of California-Los Angeles,Department of Radiology, David Geffen School of Medicine, University of California-Los Angeles;

    Division of Engineering in Medicine, Department of Medicine, Brigham and Women’s Hospital, Harvard Medical School,Harvard-MIT Division of Health Sciences and Technology, Massachusetts Institute of Technology,Wyss Institute for Biologically Inspired Engineering, Harvard University,Center for Minimally Invasive Therapeutics (C-MIT), University of California-Los Angeles,Department of Radiology, David Geffen School of Medicine, University of California-Los Angeles,Department of Bioengineering, Department of Chemical and Biomolecular Engineering, Henry Samueli School of Engineering and Applied Sciences, University of California-Los Angeles,California NanoSystems Institute (CNSI), University of California-Los Angeles,WPI-Advanced Institute for Materials Research, Tohoku University,Nanotechnology Center, King Abdulaziz University,College of Animal Bioscience and Technology, Department of Bioindustrial Technologies, Konkuk University;

    Division of Engineering in Medicine, Department of Medicine, Brigham and Women’s Hospital, Harvard Medical School,Harvard-MIT Division of Health Sciences and Technology, Massachusetts Institute of Technology,Wyss Institute for Biologically Inspired Engineering, Harvard University;

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  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类
  • 关键词

    Thermoplastic materials; Thermoplastic polyurethane; Microfluidic valves and pumps; Laser micromachining; Thermal bonding;

    机译:热塑性材料;热塑性聚氨酯;微流阀和泵;激光微加工;热粘合;

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