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首页> 外文期刊>IEEE sensors journal >A Reconfigurable and Portable Highly Sensitive Biosensor Platform for ISFET and Enzyme-Based Sensors
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A Reconfigurable and Portable Highly Sensitive Biosensor Platform for ISFET and Enzyme-Based Sensors

机译：适用于ISFET和基于酶的传感器的可重构和便携式高灵敏度生物传感器平台

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摘要

This paper presents a portable low-cost biosensor platform for ion-sensitive field-effect transistor (ISFET) and enzyme-based sensors. To meet various demands of diagnosis, our portable platform is designed to perform cyclic voltammetry, amperometry, and linear sweep voltammetry for enzyme-based sensor and ISFET sensor. For compatibility with various sensors which require various electrical driving schemes, our system can be easily reconfigured by simple switches. In addition, with disposable printed-circuit-board packages, sensors can be easily replaced. Our platform was tested with various sensors in various measurement methods. In cyclic voltammetry test with a model analyte KFe(CN), a graph provided by our system has 4.79% relative error at a current peak compared with the data acquired by a 18 times more expensive commercial system. In cyclic voltammetry and amperometry tests with the laccase enzyme-based sensors, our system achieved sensitivities of 341 and 500 /mM/cm, respectively. By running a sensitive SiNW ISFET on our platform in linear sweep voltammetry, we could build a low-cost portable pH sensor system.
机译：本文提出了一种用于离子敏感场效应晶体管（ISFET）和基于酶的传感器的便携式低成本生物传感器平台。为了满足各种诊断需求，我们的便携式平台设计用于对基于酶的传感器和ISFET传感器执行循环伏安法，安培法和线性扫描伏安法。为了与需要各种电气驱动方案的各种传感器兼容，我们的系统可以通过简单的开关轻松进行重新配置。此外，使用一次性印刷电路板包装，可以轻松更换传感器。我们的平台已通过各种测量方法的各种传感器进行了测试。在使用模型分析物KFe（CN）进行的循环伏安测试中，与18倍昂贵的商用系统所获得的数据相比，我们的系统提供的图形在电流峰值处具有4.79％的相对误差。在使用漆酶的传感器进行的伏安法和安培法测试中，我们的系统分别获得了341和500 / mM / cm的灵敏度。通过在线性扫描伏安法的平台上运行灵敏的SiNW ISFET，我们可以构建低成本的便携式pH传感器系统。

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