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首页> 外文期刊>IEEE sensors journal >Rapid Antibiotic Susceptibility Testing Based on Bacterial Motion Patterns With Long Short- Term Memory Neural Networks
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Rapid Antibiotic Susceptibility Testing Based on Bacterial Motion Patterns With Long Short- Term Memory Neural Networks

机译：基于细菌运动模式的快速抗生素易感性测试，短期内存神经网络

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摘要

Antibiotic resistance is an increasing public health threat. To combat it, a fast method to determine the antibiotic susceptibility of infecting pathogens is required. Herewe present an optical imaging-basedmethod to track the motion of single bacterial cells and generate a model to classify active and inactive cells based on the motion patterns of the individual cells. The model includes an image-processing algorithm to segment individual bacterial cells and track the motion of the cells over time, and a deep learning algorithm (Long Short-Term Memory network) to learn and determine if a bacterial cell is active or inactive. By applying the model to human urine specimens spiked with an Escherichia coli lab strain, we show that the method can accurately perform antibiotic susceptibility testing as fast as 30 minutes for five commonly used antibiotics.
机译：抗生素抗性是一种越来越多的公共卫生威胁。为了对抗它，需要一种确定感染病原体的抗生素敏感性的快速方法。这里我们介绍了基于光学成像的方法，用于跟踪单一细菌单元的运动并产生模型以基于各个单元的运动模式对激活和非活动单元进行分类。该模型包括用于分段单个细菌单元的图像处理算法，并跟踪电池的运动随着时间的推移，以及深度学习算法（长短期存储器网络），用于学习和确定细菌单元是否处于活动或非活动。通过将模型应用于用大肠杆菌实验室菌株掺入的人类尿标本，我们表明该方法可以准确地进行抗生素易感性测试尽可能快地为五种常用的抗生素。

著录项

  • 来源
    《IEEE sensors journal》 |2020年第9期|4940-4950|共11页
  • 作者

    Iriya Rafael; Jing Wenwen; Syal Karan; Mo Manni; Chen Chao; Yu Hui; Hayde Shelley E.; Wang Shaopeng; Tao Nongjian;

  • 作者单位

    Arizona State Univ Sch Elect Comp & Energy Engn Tempe AZ 85287 USA|Arizona State Univ Biodesign Ctr Biosensors & Bioelect Tempe AZ 85287 USA;

    Arizona State Univ Biodesign Ctr Biosensors & Bioelect Tempe AZ 85287 USA;

    Arizona State Univ Biodesign Ctr Biosensors & Bioelect Tempe AZ 85287 USA;

    Arizona State Univ Biodesign Ctr Biosensors & Bioelect Tempe AZ 85287 USA;

    Arizona State Univ Biodesign Ctr Biosensors & Bioelect Tempe AZ 85287 USA;

    Shanghai Jiao Tong Univ Sch Biomed Engn Inst Personalized Med Shanghai 200030 Peoples R China;

    Arizona State Univ Sch Life Sci Tempe AZ 85287 USA|Arizona State Univ Biodesign Ctr Immunotherapy Vaccines & Virotherap Tempe AZ 85287 USA;

    Arizona State Univ Biodesign Ctr Biosensors & Bioelect Tempe AZ 85287 USA;

    Arizona State Univ Sch Elect Comp & Energy Engn Tempe AZ 85287 USA|Arizona State Univ Biodesign Ctr Biosensors & Bioelect Tempe AZ 85287 USA;

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  • 正文语种 eng
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  • 关键词

    Antibiotic resistance; antibiotic susceptibility testing; AST; E. coli; single cell tracking; deep learning; neural networks; long short-term memory; LSTM;

    机译：抗生素抗性;抗生素易感性测试;AST;e。大肠杆菌;单细胞追踪;深度学习;神经网络;长短期记忆;LSTM;

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