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首页> 外文期刊>IEEE sensors journal >Ex-Vivo Identification of Tumor From Parenchyma in Human Liver Using Electrochemical Impedance Spectroscopy on a Needle
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Ex-Vivo Identification of Tumor From Parenchyma in Human Liver Using Electrochemical Impedance Spectroscopy on a Needle

机译：用电化学阻抗光谱在人肝脏中肿瘤肿瘤的前体内鉴定

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摘要

Percutaneous ethanol injection for hepatocellular carcinoma and biopsy for pathological examination of lesions in the liver are widely performed using a fine needle under ultrasonography guidance. However, it is often difficult to distinguish a malignant tumor from a parenchyma via ultrasonography. This study proposes a method for identifying a malignant tumor in the liver using coplanar bipolar electrodes fabricated on a fine needle, called electrochemical impedance spectroscopy on a needle (EoN). The electrical impedances of the malignant tumor and parenchyma were measured in two pathological statuses, more specifically in human ex-vivo normal liver and in human ex-vivo cirrhotic liver. Statistically significant differences in the electrical impedance between the malignant tumor and parenchyma in each pathological status were observed in a frequency range of 0.46MHz to 1MHz (p < 0.05). Given a real-time measurement in clinical trials, the optimal frequency suggested was indicated by the largest value in the discrimination index between the malignant tumor and the parenchyma. The electrical properties (conductivity and permittivity) of the tissues were estimated to generalize the sensor output without regard to the dimension and shape of the electrodes. The values of the electrical properties of cancer in the cirrhotic liver and normal liver were significantly higher than those of each parenchyma. These experimental results imply that EoN can be used as a potential tool for identification of malignant tumors in the liver during percutaneous ethanol injection and fine needle aspiration procedures.
机译：经皮乙醇注射肝细胞癌和肝脏病变病变病理检查的活组织检查是在超声波引导下的微针在肝脏中进行的。然而，通常难以通过超声检查将恶性肿瘤与实质肿瘤区分开来。该研究提出了一种使用在针（EON）上的细针上制造的共面双极电极在肝脏中鉴定肝脏中的恶性肿瘤的方法。恶性肿瘤和实质的电气阻抗以两种病理状态测量，更具体地，在人的前体内肝脏和人的前体内肝硬化肝脏中。在0.46MHz至1MHz的频率范围内观察到每种病理状态下的恶性肿瘤和实质之间的统计学差异，在每种病理状态下观察到（P <0.05）。鉴于临床试验中的实时测量，所建议的最佳频率被恶性肿瘤与实质之间的鉴别指数中的最大值表示。估计组织的电性能（电导率和介电常数）以概括传感器输出而不考虑电极的尺寸和形状。肝硬化肝脏和正常肝脏中癌症的电学特性的值显着高于每项实质的肝硬化。这些实验结果意味着EON可以用作潜在的工具，用于在经皮乙醇注射和细针吸入程序期间鉴定肝脏中恶性肿瘤。

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