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首页> 外文期刊>IEEE sensors journal >Development of Smartphone-Based Lateral Flow Device for the Quantification of LH and E3G Hormones
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Development of Smartphone-Based Lateral Flow Device for the Quantification of LH and E3G Hormones

机译：基于智能手机的横向流动装置的发展，用于量化LH和E3G激素

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摘要

Hormone levels of urinary luteinizing hormone (LH) and Estrone-3-gluconoride (E3G) are key indicators to control reproductive health conditions of women. An "Inito" device is developed for the lateral flow measurement and is coupled to a smartphone to predict the fertile window by providing a precise estimation of the concentration of these hormones. The image acquisition and data analysis software has been developed on android platform. Lateral flow-based test strips are inserted into the Inito device and their images are captured and processed using smartphone yielding optical densities representing the concentrations of analytes. A multi-scale algorithm was developed to detect the device and eliminate the variations in resolution and aspect ratio due to smartphone variability. It also provides automatic focus point and appropriate exposure adjustment. Concentration of LH and E3G were quantified by locating and segmenting the respective hormonal lines. The study was validated using a standard clinical lateral flow assay reader. The Inito reader yielded a linear correlation of R-2 > 0.99 suggesting a high degree of agreement with the gold standard. In addition, inter-phone repeatability of the Inito yielded very good correlation. The proposed Inito device can be very useful in point of care (PoC) settings.
机译：激素水平的泌尿丁氏素激素（LH）和Estrone-3-Gluconoride（E3G）是控制妇女生殖健康状况的关键指标。为横向流量测量开发了“初始”设备，并且通过提供精确估计这些激素的浓度来耦合到智能手机以预测肥沃窗口。在Android平台上开发了图像采集和数据分析软件。基于横向流动的测试条插入到INITO设备中，并且使用智能手机捕获并处理其图像，从而产生代表分析物浓度的光密度。开发了一种多尺度算法来检测设备，并由于智能手机可变性而消除分辨率和宽高比的变化。它还提供自动焦点和适当的曝光调整。通过定位和分割各自的激素系来量化LH和E3G的浓度。使用标准临床横向流动测定读数验证该研究。 Inito Reader产生了R-2> 0.99的线性相关性，表明与金标准的高度协议。此外，Inito的电话间重复性产生了非常好的相关性。所提出的Inito设备可以在护理点（POC）设置中非常有用。

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