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Cancer: What's luck got to do with it?

机译:巨蟹座:这和运气有什么关系?

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摘要

The idea that cancer develops due to the random build-up of mutations from mistakes made during cell division is not new.1 This theory, called the somatic mutation theory of tumour development, leads to the hypothesis that body tissues with a relatively high number of total stem cell replication events will develop tumours more often. In a recent article in Science, Johns Hopkins scientists Cristian Tomasetti and Bert Vogelstein offered an elegant test of this theory that we are certain has many scientists asking, "why didn't I do that?"2 They were able to collect data on volume and stem cell replication rates for a number of body tissues. They used these to estimate the total number of stem cell replication events in a lifetime for each tissue and subsequently demonstrated a remarkably strong relationship between those estimates and the lifetime risk of cancer in those tissues.
机译:癌症是由于细胞分裂过程中的错误而随机产生的突变而形成的,这一观点并不新鲜。1这一被称为肿瘤发展的体细胞突变理论的理论提出了这样的假设,即人体组织中相对大量的组织总干细胞复制事件将更频繁地发展为肿瘤。在《科学》杂志的最新文章中,约翰·霍普金斯大学的科学家克里斯蒂安·托马塞蒂(Cristian Tomasetti)和贝特·沃格斯坦(Bert Vogelstein)对这一理论进行了优雅的检验,我们确信许多科学家都在问:“我为什么不这样做?” 2他们能够收集大量的数据以及许多身体组织的干细胞复制率。他们使用这些数据来估计每个组织一生中干细胞复制事件的总数,随后证明了这些估计值与这些组织中癌症的终生风险之间的密切关系。

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  • 来源
    《Significance》 |2015年第2期|40-42|共3页
  • 作者单位

    Information Initiative at Duke University;

    School of Electrical and Computer Engineering at Duke University;

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  • 原文格式 PDF
  • 正文语种 eng
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