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首页> 外文期刊>IEEE Journal of Solid-State Circuits >Nanostructured CMOS Wireless Ultra-Wideband Label-Free PCR-Free DNA Analysis SoC
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Nanostructured CMOS Wireless Ultra-Wideband Label-Free PCR-Free DNA Analysis SoC

机译：纳米CMOS无线超宽带，无标记，无PCR，DNA分析SoC

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摘要

A fully integrated 54-channel wireless fast-scan cyclic voltammetry DNA analysis SoC is presented. The microsystem includes 546 3D nanostructured and 54 2D gold DNA sensing microelectrodes as well as 54 pH sensors. Each channel consists of a chopper-stabilized current conveyer with dynamic element matching. It is utilized as the amperometric readout circuit with a linear resolution from 8.6 pA to 350 nA. The on-chip programmable waveform generator provides a wide range of user-controlled rate and amplitude parameters with a maximum scan range of 1.2 V, and scan rate ranging between 0.1 mV/sec to 300 V/sec. A digital ultra-wideband transmitter based on a delay line architecture provides wireless data communication with data rates of up to 50 Mb/sec while consuming 400 µW. The 3 mm × 3 mm prototype fabricated in a 0.13 µm standard CMOS technology has been validated in prostate cancer synthetic DNA detection with 10 aM label-free PCR-free detection limit. Each channel occupies an area of only 0.06 mm 2 and consumes 42 µW of power from a 1.2 V supply.
机译：提出了一个完全集成的54通道无线快速扫描循环伏安法DNA分析SoC。该微系统包括546种3D纳米结构和54种2D金DNA感测微电极以及54个pH传感器。每个通道均包含一个具有动态元件匹配功能的斩波稳定电流传送器。它被用作电流分辨率读出电路，其线性分辨率为8.6 pA至350 nA。片上可编程波形发生器提供了广泛的用户控制的速率和幅度参数，最大扫描范围为1.2 V，扫描速率范围为0.1 mV / sec至300 V / sec。基于延迟线架构的数字超宽带发射机可提供高达50 Mb / sec的数据速率的无线数据通信，而功耗仅为400 µW。采用0.13 µm标准CMOS技术制造的3 mm×3 mm原型已在前列腺癌合成DNA检测中得到验证，具有10 aM无标记的无PCR检测限。每个通道仅占0.06 mm 2的面积，并通过1.2 V电源消耗42 µW的功率。

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