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首页> 外文期刊>IEEE Journal of Solid-State Circuits >Active CMOS Sensor Array for Electrochemical Biomolecular Detection
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Active CMOS Sensor Array for Electrochemical Biomolecular Detection

机译：用于电化学生物分子检测的有源CMOS传感器阵列

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摘要

Electrochemical sensing of biomolecules eliminates the need for the bulky and expensive optical instrumentation required in traditional fluorescence-based sensing assays. Integration of the sensor interface electrodes and active electrochemical detection circuitry on a CMOS substrate miniaturizes the sensing platform, enhancing its portability for use in point-of-care applications, while enabling the high-throughput, highly parallel analysis characteristic of traditional microarrays. This paper describes the design of a four-by-four active sensor array for multiplexed electrochemical biomolecular detection in a standard 0.25-$mu{hbox {m}}$ CMOS process. Integrated potentiostats, comprised of control amplifiers and dual-slope analog-to-digital converters, stimulate the electrochemical cell and detect the current flowing through the on-chip gold electrodes at each sensor site that results from biomolecular reactions occurring on the chip surface. Post-processing steps needed to fabricate a biologically-compatible surface-electrode array in CMOS that can withstand operation in a harsh electrochemical environment are also described. Experimental results demonstrating the proper operation of the active CMOS array for biomolecular detection include cyclic voltammetry of a reversible redox species, DNA probe density characterization, as well as quantitative and specific DNA hybridization detection.
机译：生物分子的电化学感应消除了对传统的基于荧光的感应分析所需要的庞大而昂贵的光学仪器的需求。传感器接口电极和有源电化学检测电路在CMOS基板上的集成使传感平台小型化，增强了其在即时医疗应用中的便携性，同时实现了传统微阵列的高通量，高度并行分析特性。本文介绍了在标准0.25-μmCMOS工艺中用于多重电化学生物分子检测的四乘四有源传感器阵列的设计。集成的稳压器由控制放大器和双斜率模数转换器组成，可以刺激电化学电池并检测流过芯片表面金电极的电流，这些电流是在每个传感器位置上由芯片表面发生的生物分子反应产生的。还描述了在CMOS中制造可耐受恶劣的电化学环境中操作的生物相容性表面电极阵列所需的后处理步骤。演示有源CMOS阵列用于生物分子检测的正确操作的实验结果包括可逆氧化还原物质的循环伏安法，DNA探针密度表征以及定量和特异性DNA杂交检测。

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