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首页> 外文期刊>IEEE Journal of Solid-State Circuits >A 0.18-Μm CMOS bioluminescence detection lab-on-chip
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A 0.18-Μm CMOS bioluminescence detection lab-on-chip

机译：0.18μmCMOS生物发光检测芯片实验室

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摘要

The paper describes a bioluminescence detection lab-on-chip consisting of a fiber-optic faceplate with immobilized luminescent reporters/probes that is directly coupled to an optical detection and processing CMOS system-on-chip (SoC) fabricated in a 0.18-Μm process. The lab-on-chip is customized for such applications as determining gene expression using reporter gene assays, determining intracellular ATP, and sequencing DNA. The CMOS detection SoC integrates an 8 × 16 pixel array having the same pitch as the assay site array, a 128-channel 13-bit ADC, and column-level DSP, and is fabricated in a 0.18-Μm image sensor process. The chip is capable of detecting emission rates below 10-6 lux over 30 s of integration time at room temperature. In addition to directly coupling and matching the assay site array to the photodetector array, this low light detection is achieved by a number of techniques, including the use of very low dark current photodetectors, low-noise differential circuits, high-resolution analog-to-digital conversion, background subtraction, correlated multiple sampling, and multiple digitizations and averaging to reduce read noise. Electrical and optical characterization results as well as preliminary biological testing results are reported.
机译：该论文描述了一种生物发光检测芯片实验室，该芯片实验室由带固定化发光报告器/探针的光纤面板组成，该面板直接与以0.18μm工艺制造的光学检测和处理CMOS片上系统（SoC）耦合。芯片实验室是为以下应用而定制的：使用报告基因测定法确定基因表达，确定细胞内ATP以及对DNA测序。 CMOS检测SoC集成了一个8×16像素阵列（具有与化验位点阵列相同的间距），一个128通道的13位ADC和列级DSP，并以0.18μm的图像传感器工艺制造。该芯片能够在室温下30秒的积分时间内检测到低于10-6 lux的发射率。除了直接将化验位点阵列耦合和匹配到光电探测器阵列之外，这种低光检测还通过多种技术来实现，包括使用极低的暗电流光电探测器，低噪声差分电路，高分辨率的模数转换器。 -数字转换，背景减法，相关的多次采样以及多次数字化和求平均以减少读取噪声。报告了电学和光学表征结果以及初步的生物学测试结果。

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