Plasma levels of angiostatin and endostatin remain unchanged for the first 3 weeks after colorectal cancer surgery

H. M. C. Shantha Kumara; Samer T. Tohme; Xiaohong Yan; Abu Nasar; Anthony J. Senagore; Matthew F. Kalady; Neil Hyman; Ik Y. Kim; Richard L. Whelan

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Plasma levels of angiostatin and endostatin remain unchanged for the first 3 weeks after colorectal cancer surgery

机译：结直肠癌手术后的前三周，血管抑素和内皮抑素的血浆水平保持不变

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Introduction Angiostatin and endostatin are endogenous inhibitors of angiogenesis with anticancer effects. After minimally invasive colorectal resection (MICR), blood levels of the proangiogenic factors vascular endothelial growth factor (VEGF) and angiopoetin 2 (Ang-2) are elevated for 2–4 weeks. Also, postoperative human plasma from weeks 2 and 3 after MICR has been shown to stimulate endothelial cell proliferation and migration, which are critical to angiogenesis. This proangiogenic state may stimulate tumor growth early after MICR. Surgery’s impact on angiostatin and endostatin is unknown. This study’s purpose is to determine perioperative plasma levels of these two proteins in colorectal cancer (CRC) patients undergoing MICR.

机译：简介血管抑素和内皮抑素是血管生成的内源性抑制剂，具有抗癌作用。在进行微创结直肠切除术（MICR）后，促血管生成因子血管内皮生长因子（VEGF）和血管生成素2（Ang-2）的血液水平升高了2-4周。而且，已显示MICR后2周和3周后的人血浆可刺激内皮细胞增殖和迁移，这对血管生成至关重要。这种促血管生成状态可在MICR早期刺激肿瘤生长。手术对血管抑素和内皮抑素的影响尚不清楚。这项研究的目的是确定接受MICR的结直肠癌（CRC）患者这两种蛋白的围手术期血浆水平。

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《Surgical Endoscopy》 |2011年第6期|p.1939-1944|共6页
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H. M. C. Shantha Kumara; Samer T. Tohme; Xiaohong Yan; Abu Nasar; Anthony J. Senagore; Matthew F. Kalady; Neil Hyman; Ik Y. Kim; Richard L. Whelan;
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1. Plasma levels of angiostatin and endostatin remain unchanged for the first 3 weeks after colorectal cancer surgery. [J] . Kumara HM, Tohme ST, Yan X, Surgical Endoscopy . 2011,第6期

机译：结直肠癌手术后的前三周，血管抑素和内皮抑素的血浆水平保持不变。
2. A prospective analysis of plasma endostatin levels in colorectal cancer patients with liver metastases. [J] . Feldman AL, Alexander HR Jr, Bartlett DL, Annals of surgical oncology . 2001,第9期

机译：大肠癌肝转移患者血浆内皮抑素水平的前瞻性分析。
3. Plasma levels of the proangiogenic protein CXCL16 remains elevated for 1?month after minimally invasive colorectal cancer resection [J] . H. M. C. Shantha Kumara, Erica Pettke, Abhinit Shah, World Journal of Surgical Oncology . 2018,第1期

机译：微创结直肠癌切除术后1个月，血浆中促血管生成蛋白CXCL16的水平仍保持升高
4. Plasma Levels of VEGF-C in Colorectal Cancer [C] . T. Ishiguro, T. Gonda, T. Osawa, International Society of University Colon and Rectal Surgeons . 2006

机译：直肠癌中VEGF-C的血浆水平
5. Iron and Lactoferrin Levels Remain Unchanged in Parkin Deficient Mouse Brains: Implications for Parkinson's Disease Etiology [D] . Baker, Hanan. 2015

机译：铁和乳铁蛋白水平在帕金缺乏症小鼠大脑中保持不变：对帕金森氏病病因学的影响
6. Plasma levels of the proangiogenic protein CXCL16 remains elevated for 1 month after minimally invasive colorectal cancer resection [O] . H. M. C. Shantha Kumara, Erica Pettke, Abhinit Shah, 2018

机译：微创结直肠癌切除术后1个月血浆促血管生成蛋白CXCL16的水平保持升高
7. Plasma levels of the proangiogenic protein CXCL16 remains elevated for 1 month after minimally invasive colorectal cancer resection [O] . H. M. C. Shantha Kumara, Erica Pettke, Abhinit Shah, 2018

机译：在微创结直肠癌切除术后1个月后，血浆蛋白CXCL16的血浆水平仍升高1个月

Plasma levels of angiostatin and endostatin remain unchanged for the first 3 weeks after colorectal cancer surgery

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