...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Surgical infections >Linezolid-lnduced Lactic Acidosis followed by Severe Hypophosphatemia after Discontinuation of Linezolid
【24h】

Linezolid-lnduced Lactic Acidosis followed by Severe Hypophosphatemia after Discontinuation of Linezolid

机译：利奈唑胺停药后，利奈唑胺引起的乳酸酸中毒，继而发生严重低磷酸盐血症

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Linezolid is a synthetic oxazolidinone used to treat serious infections caused by gram-positive bacteria that are resistant to other antibiotics. Linezolid acts by binding to bacterial ribosomes and inhibiting protein synthesis, which, however, may cause adverse effects in human beings because of similarities between bacterial and mitochondrial ribosomes [1-3]. We report the case of a patient in whom the use of linezolid was associated with lactic acidosis, a rare adverse event caused by mitochondrial toxicity. The patient also developed life-threatening hypophosphatemia after discontinuing linezolid. Multiple etiologies may explain the hypophosphatemia in this patient; however, we assume that withdrawal of linezolid may have led to increased phosphorus consumption in the reactivated mitochondrial respiratory chain in association with protein synthesis. Because the development of severe hypophosphatemia after discontinuation of linezolid has not been reported previously, the present case may stimulate study toward understanding the pathophysiologic mechanisms underlying severe hypophosphatemia in similar cases. This may be the first report of additional side effects after the withdrawal of linezolid, of which physicians must become aware because linezolid is being increasingly used in clinical practice.
机译：利奈唑胺是一种合成的恶唑烷酮，用于治疗对其他抗生素具有耐药性的革兰氏阳性细菌引起的严重感染。利奈唑胺通过结合细菌核糖体和抑制蛋白质合成而起作用，但是由于细菌和线粒体核糖体之间的相似性，利奈唑胺可能对人类造成不利影响[1-3]。我们报告了一起患者使用利奈唑胺与乳酸性酸中毒相关的病例，这是一种罕见的由线粒体毒性引起的不良事件。停用利奈唑胺后，患者还会发生危及生命的低磷酸盐血症。多种病因可能解释了该患者的低磷血症。但是，我们认为撤回利奈唑胺可能导致与蛋白质合成相关的线粒体呼吸链重新激活增加了磷的消耗。由于先前未曾报道利奈唑胺停药后出现严重的低磷血症，因此本病例可能促进研究，以了解类似病例中严重的低磷血症的病理生理机制。这可能是利奈唑胺停用后其他副作用的首次报道，医师必须意识到这一点，因为利奈唑胺在临床实践中越来越多地被使用。

著录项

  • 来源
    《Surgical infections》 |2013年第2期|229-230|共2页
  • 作者

    Atsushi Miyawaki; Takahiro Ueda; Atsunori Nakao; Masaru Adachi; Munehiko Ohya; Isamu Yamada; Yoshio Takesue; Joji Kotani;

  • 作者单位

    Department of Emergency and Critical Care Medicine, Hyogo College of Medicine, Hyogo, Japan;

    Department of Emergency and Critical Care Medicine, Hyogo College of Medicine, Hyogo, Japan;

    Department of Emergency and Critical Care Medicine, Hyogo College of Medicine, Hyogo, Japan;

    Department of Emergency and Critical Care Medicine, Hyogo College of Medicine, Hyogo, Japan;

    Department of Emergency and Critical Care Medicine, Hyogo College of Medicine, Hyogo, Japan;

    Department of Emergency and Critical Care Medicine, Hyogo College of Medicine, Hyogo, Japan;

    Department of Emergency and Critical Care Medicine, Hyogo College of Medicine, Hyogo, Japan;

    Department of Emergency and Critical Care Medicine Hyogo College of Medicine 1-1, Mukogawa-cho Nishinomiya, Hyogo 663-8501, Japan;

  • 收录信息 美国《化学文摘》(CA);
  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类
  • 关键词

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号