The large grey area between 'bona fide' and 'rogue' stem cell interventions - Ethical acceptability and the need to include local variability

Sleeboom-Faulkner Margaret Elizabeth

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The large grey area between 'bona fide' and 'rogue' stem cell interventions - Ethical acceptability and the need to include local variability

机译：“善意”和“流氓”干细胞干预之间的较大灰色区域-伦理上的可接受性以及包括局部变异性的需求

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This article aims to put into perspective the binary opposition between 'scientific' clinical research trials and 'rogue' experimental stem cell therapies, and to show why the ethics criteria used by the dominant science community are not suitable for distinguishing between adequate and inadequate treatments. By focusing on the grey area between clinical stem cell trials and stem cell experimentation, the experimental space where patients, medical professionals and life scientists negotiate for diverging reasons and aims, I show why idealised notions of ethics are not feasible for many stem cell scientists in low- and middle-income countries.

机译：本文旨在透视“科学”临床研究试验和“流氓”实验性干细胞疗法之间的二元对立，并说明为什么占主导地位的科学界所采用的伦理标准不适合区分适当和不足的治疗方法。通过关注临床干细胞试验和干细胞实验之间的灰色区域，患者，医学专业人员和生命科学家出于不同原因和目标进行谈判的实验空间，我展示了为什么理想的伦理学概念对于许多干细胞科学家而言并不可行。中低收入国家。

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来源
《Technological forecasting and social change》 |2016年第8期|76-86|共11页
作者
Sleeboom-Faulkner Margaret Elizabeth;
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作者单位

Univ Sussex, Dept Anthropol, ARTS C209, Brighton BN1 9SJ, Sussex, England;

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收录信息美国《科学引文索引》(SCI);美国《工程索引》(EI);
原文格式 PDF
正文语种 eng
中图分类
关键词
China; Stem cells; Clinical trials; Experimentation; Bionetworking;

机译：中国;干细胞;临床试验;实验;生物网络;

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1. Generation of Human Induced Pluripotent Stem Cell‐Derived Bona Fide Neural Stem Cells for Ex Vivo Gene Therapy of Metachromatic Leukodystrophy [J] . Vasco Meneghini, Giacomo Frati, Davide Sala, Stem cells translational medicine. . 2018,第2期

机译：人类诱导的多能干细胞衍生的善意神经干细胞的产生，用于异基因白细胞营养障碍的离体基因治疗
2. Identification and analysis of a minority fraction in a U87 cell line Do side-population cells represent bona fide stem cell-like cancer cells? [J] . Changwei Gu, Qingfang Sun, Jiang Zhu, 中国神经再生研究（英文版） . 2009,第011期

机译：U87细胞系中少数成分的鉴定和分析侧群细胞代表真正的干细胞样癌细胞吗？
3. Identification and analysis of a minority fraction in a 387 cell lineDo side-population cells represent bona fide stem cell-like cancer cells？ [J] . Changwei Gu, Qingfang Sun, Jiang Zhu, 中国神经再生研究：英文版 . 2009,第011期

机译：387细胞系中少数成分的鉴定和分析侧群细胞代表真正的干细胞样癌细胞吗？
4. Ethical (and political) issues in research with human stem cells [C] . Thomas H. Murra symposium on Stem cells :nuclear reprogramming and therapeutic applications . 2005

机译：人体干细胞研究中的伦理（和政治）问题
5. When does a human being gain a moral right to life? An ethical and metaphysical study of abortion and embryonic stem cell research. [D] . Manninen, Bertha Alvarez. 2006

机译：人什么时候可以获得精神生命权？堕胎和胚胎干细胞研究的伦理和形而上学研究。
6. Generation of Human Induced Pluripotent Stem Cell‐Derived Bona Fide Neural Stem Cells for Ex Vivo Gene Therapy of Metachromatic Leukodystrophy [O] . Vasco Meneghini, Giacomo Frati, Davide Sala, 2017

机译：人类诱导的多能干细胞衍生的善意神经干细胞的产生用于异基因白细胞营养障碍的离体基因治疗
7. The large grey area between ‘bona fide’ and ‘rogue’ stem cell interventions — Ethical acceptability and the need to include local variability [O] . Sleeboom-Faulkner Margaret Elizabeth 2016

机译：“善意”和“流氓”干细胞干预之间的较大灰色区域-伦理上的可接受性以及包括局部可变性的需求

The large grey area between 'bona fide' and 'rogue' stem cell interventions - Ethical acceptability and the need to include local variability

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