Dual-Mode Vaccines

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Dual-Mode Vaccines

机译：双模疫苗

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Vaccines are unarguably one of the greatest success stories in medical history, eliminating or largely curtailing numerous age-old scourges such as smallpox and polio. But researchers' track record in coming up with effective vaccines for today's major and emerging diseases is, by and large, dismal. A Yale University spinoff, Vaxinnate, hopes to use recent breakthroughs in basic immunology to re-invigorate vaccine development and create new vaccines for cancer, West Nile virus, and influenza.

机译：毫无疑问，疫苗是医学史上最伟大的成功案例之一，它消除了或大大减少了天花和脊髓灰质炎等许多古老的祸害。但是研究人员在为当今的主要和新兴疾病提供有效疫苗方面的往绩总体上是令人沮丧的。耶鲁大学的分公司Vaxinnate希望利用基础免疫学领域的最新突破来重振疫苗开发，并开发出针对癌症，西尼罗河病毒和流感的新型疫苗。

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《Technology Review》 |2004年第10期|p.81|共1页
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1. Pandemic influenza A(H1N1 pdm09) vaccine induced high levels of influenza-specific IgG and IgM antibodies as analyzed by enzyme immunoassay and dual-mode multiplex microarray immunoassay methods [J] . Kazakova Anna, Kakkola Laura, Ziegler Thedi, Vaccine . 2020,第8期

机译：大流行性流感A（H1N1 PDM09）疫苗诱导高含量的甲型甲型特异性IgG和IgM抗体，如酶免疫测定和双模多重微阵列免疫测定方法分析
2. Paradoxical Decrease in the Capture and Lymph Node Delivery of Cancer Vaccine Antigen Induced by a TLR4 Agonist as Visualized by Dual-Mode Imaging [J] . Kadayakkara Deepak K., Korrer Michael J., Bulte Jeff W. M., Cancer research: The official organ of the American Association for Cancer Research, Inc . 2015,第1期

机译：由双模式成像可视化由TLR4激动剂诱导的癌症疫苗抗原的捕获和淋巴结传递中的自相矛盾的减少。
3. Efficient modulation of T-cell response by dual-mode, single-carrier delivery of cytokine-targeted siRNA and DNA vaccine to antigen-presenting cells. [J] . Singh A, Nie H, Ghosn B Molecular therapy: the journal of the American Society of Gene Therapy . 2008,第12期

机译：通过将靶向细胞因子的siRNA和DNA疫苗双模式，单载体递送至抗原呈递细胞，有效调节T细胞反应。
4. Predicting Vaccine Hesitancy and Vaccine Sentiment Using Topic Modeling and Evolutionary Optimization [C] . Gokul S. Krishnan, S. Sowmya Kamath, Vijayan Sugumaran International Conference on Applications of Natural Language to Information Systems . 2021

机译：使用主题建模和进化优化预测疫苗犹豫和疫苗情绪
5. Rational vaccine development 1) Design of a triantigen nasal anthrax vaccine candidate 2) A novel lecithin based nanoparticle as a vaccine delivery system. [D] . Sloat, Brian R. 2010

机译：合理的疫苗开发1）设计三抗原鼻炭疽疫苗候选者2）基于卵磷脂的新型纳米颗粒作为疫苗输送系统。
6. Paradoxical decrease in the capture and lymph node delivery of cancer vaccine antigen induced by TLR4 agonists as visualized by dual-mode imaging [O] . Deepak K. Kadayakkara, Michael J. Korrer, Jeff W.M. Bulte, -1

机译：通过双模式成像观察到的TLR4激动剂诱导的癌症疫苗抗原的捕获和淋巴结转移的自相矛盾的减少
7. Construction of ( n + 1 ) $(n+1)$ -dimensional dual-mode nonlinear equations: multiple shock wave solutions for ( 3 + 1 ) $(3+1)$ -dimensional dual-mode Gardner-type and KdV-type [O] . Ali Jaradat, M. M. M. Jaradat, Mohd Salmi Md Noorani, 2019

机译：（n + 1）$（n + 1）$（n + 1）$ -dimensional双模式非线性方程式：用于（3 + 1）$（3 + 1）$（3 + 1）$ -dimensional双模式Gardner-type和KDV-的多重冲击波解决方案类型

Dual-Mode Vaccines

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