Single-Molecule Gene Sequencer

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Single-Molecule Gene Sequencer

机译：单分子基因测序仪

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Most gene sequencers require thousands of copies of a DNA strand. But Helicos BioSciences' new system can sequence a single molecule, simplifying sample preparation and decreasing cost. It can also gauge gene activity by counting messenger RNAs, molecules that help translate genes into proteins; its ability to rapidly determine chemicals' effects on gene activity could speed drug development. With improvements to just its reagent kits, the system could ultimately deliver the $ 1,000 genome.

机译：大多数基因测序仪需要DNA链的数千个拷贝。但是Helicos BioSciences的新系统可以对单个分子进行测序，从而简化了样品制备并降低了成本。它还可以通过计算信使RNA（可帮助将基因转化为蛋白质的分子）来评估基因活性。快速确定化学物质对基因活性的影响的能力可以加快药物开发。通过对其试剂盒的改进，该系统最终可以交付1,000美元的基因组。

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《Technology Review》 |2008年第1期|p.29|共1页
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1. Erratum: A reference bacterial genome dataset generated on the MinIONTM portable single-molecule nanopore sequencer [J] . Joshua Quick, Aaron R Quinlan, Nicholas J Loman GigaScience . 2015,第3期

机译：勘误：在MinION TM 便携式单分子纳米孔测序仪上生成的参考细菌基因组数据集
2. A reference bacterial genome dataset generated on the MinION? portable single-molecule nanopore sequencer [J] . Joshua Quick, Aaron R Quinlan, Nicholas J Loman GigaScience . 2014,第2期

机译：在MinION？上生成的参考细菌基因组数据集。便携式单分子纳米孔测序仪
3. Unamplified cap analysis of gene expression on a single-molecule sequencer. [J] . Kanamori Katayama M, Itoh M, Kawaji H, Genome research . 2011,第7期

机译：单分子测序仪上基因表达的未扩增帽分析。
4. Single-molecule interactions studied by using a modified DNA sequencer: A comparison with surface plasmon resonance data [C] . Jens Sobek, Stefan Schauer, Hubert Rehrauer, Reporters, markers, dyes, nanoparticles, and molecular probes for biomedical applications V . 2013

机译：使用改良的DNA测序仪研究单分子相互作用：与表面等离振子共振数据的比较
5. Single-Molecule Studies of Sequence and Structure Dependent DNA Binding by SA1 and SA2 [D] . Countryman, Preston James. 2016

机译：SA1和SA2的序列和结构依赖性DNA结合的单分子研究
6. Erratum: A reference bacterial genome dataset generated on the MinIONTM portable single-molecule nanopore sequencer [O] . Joshua Quick, Aaron R Quinlan, Nicholas J Loman 2015

机译：勘误：在MinIONTM便携式单分子纳米孔测序仪上生成的参考细菌基因组数据集
7. Erratum: A reference bacterial genome dataset generated on the MinION portable single-molecule nanopore sequencer [O] . 2015

机译：勘误：在MinION便携式单分子纳米孔测序仪上生成的参考细菌基因组数据集
8. DNA Sequences of Genes Encoding Acinetobacter calcoaceticus Protocatechuate 3,4-Dioxygenase: Evidence Indicating Shuffling of Genes and of DNA Sequences within Genes during Their Evolutionary Divergence [R] . Hartnett, C., Neidle, E. L., Ngai, K. L., 1990

机译：编码醋酸钙不动杆菌原儿茶酸3,4-二氧化酶基因的DNa序列：证据表明基因在进化发散过程中基因和DNa序列的改组

Single-Molecule Gene Sequencer

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