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U.S. stem cell researchers confront uncertain financing and arcane restrictions

机译:美国干细胞研究人员面临不确定的融资和神秘的限制

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On august 9, 2001, Mathew "willy" lensch sat with his wife in their Oregon living room and watched President George W. Bush speak to the nation. Millions of Americans had their TVs on, but unlike most of them, Lensch was, as he puts it, "on the edge of my chair, the rest of the universe ceasing to exist." Lensch was finishing his PhD in molecular and medical genetics. His research specialty was a genetic malady called Fan-coni anemia, which often kills its victims before they reach adolescence. The disease is caused by the malfunctioning of special cells in the bone marrow: stem cells, the precursor cells that create and maintain the body's supply of blood cells. Fanconi victims' best hope for a cure, Lensch believed, lay in re-creating their missing blood cells from embryonic stem cells—stem cells derived from an early human embryo, which are unusually adaptable and changeable. Earlier that year, Lensch had accepted a posi-tion with a brand-new stem cell group that is now based at Children's Hospital Boston, a prominent biomedical research center.
机译:2001年8月9日,Mathew“ willy” lensch和他的妻子坐在俄勒冈州的客厅里,看着乔治·W·布什总统向美国讲话。数以百万计的美国人开着电视,但是与大多数人不同的是,伦施(Lensch)说:“在我椅子的边缘,宇宙的其余部分不再存在。” Lensch正在完成他的分子和医学遗传学博士学位。他的研究专长是一种称为Fan-coni贫血的遗传性疾病,通常可在受害者到青春期之前将其杀死。该疾病是由骨髓中特殊细胞的功能异常引起的:干细胞是创造并维持人体血细胞供应的前体细胞。 Lensch认为,范科尼受害者的最大治疗希望在于依靠胚胎干细胞(源自人类早期胚胎的干细胞)重新创造失踪的血细胞,这种干细胞异常适应和多变。那年早些时候,Lensch接受了一个崭新的干细胞小组的职位,该小组现在设在著名的生物医学研究中心波士顿儿童医院。

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