...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>The Analyst >Effects of the confluence rate on the FTIR spectrum of PC-3 prostate cancer cells in culture
【24h】

Effects of the confluence rate on the FTIR spectrum of PC-3 prostate cancer cells in culture

机译：汇合速率对培养的PC-3前列腺癌细胞FTIR谱的影响

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Recently, the possibility of using IR spectroscopy to fingerprint the mode of action of potent antitumorndrugs on cancer cells at sub-lethal concentrations has been demonstrated by comparing spectranrecorded from untreated or drug-treated cells. The present study investigates the potential interferencenof the cell culture confluence rate on cell FTIR signature. Significant spectral differences were observednon cells harvested at different confluence rates. Yet, these differences were weak when compared tonthose induced by sub-lethal ouabain concentrations, used as a model of cardenolide drug. Furthermore,nprincipal component analysis reveals that the impact of the confluence rate, above 50% coverage, on thenFTIR spectra is essentially unique and orthogonal to the one induced by the drug model.
机译：最近，通过比较未处理或药物处理的细胞记录的光谱，已经证明了使用IR光谱法对亚致死浓度的有效抗肿瘤药物对癌细胞的作用模式进行指纹识别的可能性。本研究调查了细胞培养融合率对细胞FTIR信号的潜在干扰。观察到显着的光谱差异，未以不同的汇合速率收获细胞。然而，当比较由亚致命哇巴因浓度诱导的扁豆糖时，这些差异是微弱的。此外，主要成分分析表明，汇合率（覆盖率超过50％）对FTIR光谱的影响是独特的，并且与药物模型诱导的光谱正交。

著录项

  • 来源
    《The Analyst》 |2010年第12期|p.3048-3051|共4页
  • 作者

    Régis Gasper and Erik Goormaghtigh;

  • 作者单位

    Center for Structural Biology and Bioinformatics, Laboratory for theStructure and Function of Biological Membranes, Campus PlaineCP206/02, Universitu0002e Libre de Bruxelles, Bld du Triomphe 2, CP206/2,B1050 Brussels, Belgium. E-mail: egoor@ulb.ac.be;

    Fax: +32-2-650-53-82;

    Tel: +32-2-650-53-62† This article is part of a themed issue on Optical Diagnosis. This issueincludes work presented at SPEC 2010 Shedding Light on Disease:Optical Diagnosis for the New Millennium, which was held inManchester, UK June 26th – July 1st 2010.‡ EG is Director of Research with the Fonds National de la RechercheScientifique (FNRS, Belgium).;

  • 收录信息
  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类
  • 关键词

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号