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首页> 外文期刊>The Cerebellum >Cerebellar Motor Function in Spina Bifida Meningomyelocele
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Cerebellar Motor Function in Spina Bifida Meningomyelocele

机译：脊柱裂双脑膜脊髓小脑脊髓小脑运动功能

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摘要

Spina bifida meningomyelocele (SBM), a congenital neurodevelopmental disorder, involves dysmorphology of the cerebellum, and its most obvious manifestations are motor deficits. This paper reviews cerebellar neuropathology and motor function across several motor systems well studied in SBM in relation to current models of cerebellar motor and timing function. Children and adults with SBM have widespread motor deficits in trunk, upper limbs, eyes, and speech articulators that are broadly congruent with those observed in adults with cerebellar lesions. The structure and function of the cerebellum are correlated with a range of motor functions. While motor learning is generally preserved in SBM, those motor functions requiring predictive signals and precise calibration of the temporal features of movement are impaired, resulting in deficits in smooth movement coordination as well as in the classical cerebellar triad of dysmetria, ataxia, and dysarthria. That motor function in individuals with SBM is disordered in a manner phenotypically similar to that in adult cerebellar lesions, and appears to involve similar deficits in predictive cerebellar motor control, suggests that age-based cerebellar motor plasticity is limited in individuals with this neurodevelopmental disorder.
机译：先天性神经发育障碍脊柱裂脑膜脊髓膨出症（SBM）涉及小脑畸形，其最明显的表现是运动功能障碍。本文回顾了在SBM中已深入研究的几个运动系统中的小脑神经病理学和运动功能，并与当前的小脑运动和计时功能模型相关。患有SBM的儿童和成人在躯干，上肢，眼睛和言语发音器中普遍存在运动缺陷，这与在小脑病变的成年人中观察到的运动缺陷大致相同。小脑的结构和功能与一系列运动功能相关。虽然SBM中通常保留了运动学习功能，但是那些需要预测信号和精确校准运动时间特征的运动功能受到了损害，从而导致运动协调不畅以及经典的小脑三联症，共济失调和构音障碍。具有SBM的个体的运动功能以与成人小脑病变的表型相似的方式紊乱，并且似乎在预测性小脑运动控制中涉及类似的缺陷，这表明基于年龄的小脑运动可塑性在患有这种神经发育障碍的个体中受到限制。

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  • 来源
    《The Cerebellum》 |2010年第4期|484-498|共15页
  • 作者

    Maureen Dennis; Michael S. Salman; Jenifer Juranek; Jack M. Fletcher;

  • 作者单位

    Program in Neurosciences and Mental Health Department of Psychology The Hospital for Sick Children 555 University Avenue Toronto ON M5G 1X8 Canada;

    Section of Pediatric Neurology Children’s Hospital University of Manitoba Winnipeg MB Canada;

    Developmental Pediatrics University of Texas Health Science Center at Houston Houston TX USA;

    Department of Psychology University of Houston Houston TX USA;

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  • 原文格式 PDF
  • 正文语种 eng
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  • 关键词

    Cerebellum; Motor function; Motor learning; Spina bifida; Chiari II;

    机译：小脑;运动功能;运动学习;脊柱裂;Chiari II;

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