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首页> 外文期刊>Tobacco control >Quantifying the association of low-intensity and late initiation of tobacco smoking with total and cause-specific mortality in Asia
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Quantifying the association of low-intensity and late initiation of tobacco smoking with total and cause-specific mortality in Asia

机译：量化烟草的低强度和晚期起始的结合，亚洲总造成特异性死亡率

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摘要

BackgroundLittle is known about the health harms associated with low-intensity smoking in Asians who, on average, smoke fewer cigarettes and start smoking at a later age than their Western counterparts.MethodsIn this pooled analysis of 738 013 Asians from 16 prospective cohorts, we quantified the associations of low-intensity (5 cigarettes/day) and late initiation (= 35 years) of smoking with mortality outcomes. HRs and 95% CIs were estimated for each cohort by Cox regression. Cohort-specific HRs were pooled using random-effects meta-analysis.FindingsDuring a mean follow-up of 11.3 years, 92 068 deaths were ascertained. Compared with never smokers, current smokers who consumed 5 cigarettes/day or started smoking after age 35 years had a 16%-41% increased risk of all-cause, cardiovascular disease (CVD), respiratory disease mortality and a twofold risk of lung cancer mortality. Furthermore, current smokers who started smoking after age 35 and smoked 5 cigarettes/day had significantly elevated risks of all-cause (HRs (95% CIs)=1.14 (1.05 to 1.23)), CVD (1.27 (1.08 to 1.49)) and respiratory disease (1.54 (1.17 to 2.01)) mortality. Even smokers who smoked 5 cigarettes/day but quit smoking before the age of 45 years had a 16% elevated risk of all-cause mortality; however, the risk declined further with increasing duration of abstinence.ConclusionsOur study showed that smokers who smoked a small number of cigarettes or started smoking later in life also experienced significantly elevated all-cause and major cause-specific mortality but benefited from cessation. There is no safe way to smoke-not smoking is always the best choice.
机译：背景下是关于与亚洲人的低强度吸烟有关的健康危害，平均烟雾比其西部同上的亚洲人在后期的烟雾中开始吸烟。此汇总分析来自16个未来的队列的738 013亚洲人，我们量化了低强度（＆ 5卷烟/日）和晚期启动（＆ = 35岁）吸烟的关联与死亡率结果。通过COX回归估计每个队列的HRS和95％CIS。使用随机效应Meta-Analysis合并群组的HRS .Findings追究了11.3岁的平均随访，确定了92 068年死亡。与从未吸烟者相比，目前的吸烟者消耗5岁的吸烟者/日龄为35岁以上的患者或在35岁后开始吸烟16％-41％的风险增加，心血管疾病（CVD），呼吸道疾病死亡率和A＆双重肺癌死亡率的风险。此外，目前在35岁以后开始吸烟的吸烟者和禁止烟雾/天的风险显着升高了所有原因的风险（HRS（95％CIS）= 1.14（1.05至1.23）），CVD（1.27（1.08至1.49） ）和呼吸系统（1.54（1.17至2.01））死亡率。甚至吸烟的吸烟者甚至吸烟/天，但在45岁之前戒烟有16％的危险风险升高了巨大的死亡率;然而，随着禁欲期的持续时间，风险进一步下降。结论的研究表明，吸烟的吸烟者或在生命后以后开始吸烟也显着提高了所有原因和主要原因特异性的死亡率，但受益于停止而受益。没有安全的吸烟方式是最好的选择。

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  • 来源
    《Tobacco control》 |2021年第3期|328-335|共8页
  • 作者

    Yang Jae Jeong; Yu Danxia; Shu Xiao-Ou; Freedman Neal D.; Wen Wanqing; Rahman Shafiur; Abe Sarah K.; Saito Eiko; Gupta Prakash C.; He Jiang; Tsugane Shoichiro; Gao Yu-Tang; Xiang Yong-Bing; Yuan Jian-Min; Tomata Yasutake; Tsuji Ichiro; Sugawara Yumi; Matsuo Keitaro; Ahn Yoon-Ok; Park Sue K.; Chen Yu; Pan Wen-Harn; Pednekar Mangesh; Gu Dongfeng; Sawada Norie; Cai Hui; Li Hong-Lan; Koh Woon-Puay; Wang Renwei; Zhang Shu; Kanemura Seiki; Ito Hidemi; Shin Myung-Hee; Wu Pei-Ei; Yoo Keun-Young; Ahsan Habibul; Chia Kee Seng; Boffetta Paolo; Inoue Manami; Kang Daehee; Potter John D.; Zheng Wei;

  • 作者单位

    Vanderbilt Univ Sch Med Div Epidemiol Dept Med Vanderbilt Epidemiol Ctr VanderbiltIngram Canc Ct Nashville TN 37232 USA;

    Vanderbilt Univ Sch Med Div Epidemiol Dept Med Vanderbilt Epidemiol Ctr VanderbiltIngram Canc Ct Nashville TN 37232 USA;

    Vanderbilt Univ Sch Med Div Epidemiol Dept Med Vanderbilt Epidemiol Ctr VanderbiltIngram Canc Ct Nashville TN 37232 USA;

    Natl Canc Inst Div Canc Epidemiol & Genet Natl Inst Hlth Bethesda MD USA;

    Vanderbilt Univ Sch Med Div Epidemiol Dept Med Vanderbilt Epidemiol Ctr VanderbiltIngram Canc Ct Nashville TN 37232 USA;

    Hamamatsu Univ Sch Med Res Ctr Child Mental Dev Hamamatsu Shizuoka Japan|Natl Canc Ctr Div Prevent Ctr Publ Hlth Sci Tokyo Japan;

    Natl Canc Ctr Epidemiol & Prevent Grp Ctr Publ Hlth Sci Tokyo Japan;

    Natl Canc Ctr Div Canc Stat & Integrat Ctr Canc Control & Informat Serv Tokyo Japan;

    Healis Sekhsaria Inst Publ Hlth Navi Mumbai Maharashtra India;

    Tulane Univ Sch Publ Hlth & Trop Med Dept Epidemiol New Orleans LA 70118 USA;

    Natl Canc Ctr Epidemiol & Prevent Grp Ctr Publ Hlth Sci Tokyo Japan;

    Shanghai Jiao Tong Univ Sch Med State Key Lab Oncogene & Related Genes Shanghai Peoples R China|Shanghai Jiao Tong Univ Sch Med Dept Epidemiol Shanghai Canc Inst Renji Hosp Shanghai Peoples R China;

    Shanghai Jiao Tong Univ Sch Med State Key Lab Oncogene & Related Genes Shanghai Peoples R China|Shanghai Jiao Tong Univ Sch Med Dept Epidemiol Shanghai Canc Inst Renji Hosp Shanghai Peoples R China;

    Univ Pittsburgh Canc Inst Pittsburgh PA USA|Univ Pittsburgh Grad Sch Publ Hlth Dept Epidemiol Pittsburgh PA 15260 USA;

    Tohoku Univ Grad Sch Med Div Epidemiol Sendai Miyagi Japan;

    Tohoku Univ Grad Sch Med Div Epidemiol Sendai Miyagi Japan;

    Tohoku Univ Grad Sch Med Div Epidemiol Sendai Miyagi Japan|Aichi Canc Ctr Res Inst Div Canc Epidemiol & Prevent Nagoya Aichi Japan;

    Nagoya Univ Grad Sch Med Div Canc Epidemiol Nagoya Aichi Japan;

    Seoul Natl Univ Coll Med Dept Prevent Med Seoul South Korea;

    Seoul Natl Univ Coll Med Dept Prevent Med Seoul South Korea|Seoul Natl Univ Grad Sch Dept Biomed Sci Seoul South Korea|Seoul Natl Univ Canc Res Inst Seoul South Korea;

    NYU Sch Med Dept Populat Hlth New York NY USA;

    Acad Sinica BRC Inst Biomed Sci Taipei Taiwan;

    Healis Sekhsaria Inst Publ Hlth Navi Mumbai Maharashtra India;

    Chinese Acad Med Sci & Peking Union Med Coll Fuwai Hosp Natl Ctr Cardiovasc Dis Beijing Peoples R China;

    Natl Canc Ctr Epidemiol & Prevent Grp Ctr Publ Hlth Sci Tokyo Japan;

    Vanderbilt Univ Sch Med Div Epidemiol Dept Med Vanderbilt Epidemiol Ctr VanderbiltIngram Canc Ct Nashville TN 37232 USA|Natl Canc Inst Div Canc Epidemiol & Genet Natl Inst Hlth Bethesda MD USA;

    Shanghai Jiao Tong Univ Sch Med State Key Lab Oncogene & Related Genes Shanghai Peoples R China|Shanghai Jiao Tong Univ Sch Med Dept Epidemiol Shanghai Canc Inst Renji Hosp Shanghai Peoples R China;

    Chinese Acad Med Sci & Peking Union Med Coll Fuwai Hosp Natl Ctr Cardiovasc Dis Beijing Peoples R China|Duke NUS Grad Med Sch Hlth Serv & Syst Res Singapore Singapore|Natl Univ Singapore Saw Swee Hock Sch Publ Hlth Singapore Singapore;

    Univ Pittsburgh Canc Inst Pittsburgh PA USA|Univ Pittsburgh Grad Sch Publ Hlth Dept Epidemiol Pittsburgh PA 15260 USA;

    Tohoku Univ Grad Sch Med Div Epidemiol Sendai Miyagi Japan;

    Tohoku Univ Grad Sch Med Div Epidemiol Sendai Miyagi Japan;

    Aichi Canc Ctr Res Inst Div Canc Informat & Control Nagoya Aichi Japan|Nagoya Univ Grad Sch Med Div Descript Canc Epidemiol Nagoya Aichi Japan;

    Sungkyunkwan Univ Sch Med Dept Social & Prevent Med Seoul South Korea;

    Acad Sinica BRC Inst Biomed Sci Taipei Taiwan;

    Seoul Natl Univ Coll Med Dept Prevent Med Seoul South Korea;

    Univ Chicago Ctr Canc Epidemiol & Prevent Dept Hlth Studies Chicago IL 60637 USA;

    Natl Univ Singapore Saw Swee Hock Sch Publ Hlth Singapore Singapore;

    Icahn Sch Med Mt Sinai New York NY 10029 USA;

    Natl Canc Ctr Epidemiol & Prevent Grp Ctr Publ Hlth Sci Tokyo Japan;

    Fred Hutchinson Canc Res Ctr Div Publ Hlth Sci 1124 Columbia St Seattle WA 98104 USA|Massey Univ Ctr Publ Hlth Res Wellington New Zealand|Univ Washington Dept Epidemiol Seattle WA 98195 USA;

    Vanderbilt Univ Sch Med Div Epidemiol Dept Med Vanderbilt Epidemiol Ctr VanderbiltIngram Canc Ct Nashville TN 37232 USA;

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  • 原文格式 PDF
  • 正文语种 eng
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  • 关键词

    smoking caused disease; prevention; socioeconomic status;

    机译：吸烟造成的疾病;预防;社会经济地位;

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