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Reach and effectiveness of mailed nicotine replacement therapy for smokers: 6-month outcomes in a naturalistic exploratory study

机译：邮寄尼古丁替代疗法对吸烟者的影响和有效性：一项自然主义探索性研究的6个月结果

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Background There are important inequities in smoker access to clinic-based smoking cessation services. Low barrier high-reach interventions are proposed as solutions to these inequities. Although effective, telephone quitlines, which provide multi-session counselling but no medication, have low utilization with high attrition. The objective of this study was to determine the effectiveness of free nicotine replacement therapy (NRT), brief advice and self-help materials on quit attempts and 6-month quit rates in motivated smokers. Methods In this open-label naturalistic study, 14000 treatments of 5 weeks in duration of either nicotine patch (n=10000) or nicotine gum (n=4000) were made available to all eligible adult smokers in Ontario, Canada, who called a toll-free number to register with the STOP (Smoking Treatment for Ontario Patients) Study and receive a single brief intervention. The primary outcome measure was self-reported abstinence rates at 6 months post-treatment among STOP participants. These data were compared with quit rates that were reported in a concurrent no-intervention cohort of Ontario smokers matched for eligibility. Results 16405 callers were assessed and 13143 eligible participants were mailed a treatment package with 5 weeks of NRT (choice of patch or gum), self-help and community resource materials. Among the 6261 participants who consented to follow-up, 2601 (42%) had complete follow-up data. Of those with complete follow-up data, the percentage reporting abstinence after 6 months in the treatment cohort was 21.4%, relative to 11.6% in the no-intervention cohort (rate ratio of 1.84; 95% Cl 1.79 to 1.89), with the 30-day point prevalence of 17.8% and 9.8% for the intervention and no-intervention cohorts, respectively (rate ratio 1.81; Cl 1.75 to 1.87). Conclusions Provision of free NRT by mail following a brief telephone intervention is an effective strategy to reach and assist a large number of smokers making a quit attempt.
机译：背景技术吸烟者在使用基于诊所的戒烟服务方面存在严重的不平等现象。建议采用低障碍高影响力干预措施来解决这些不平等问题。电话戒烟热线虽然有效，但可以提供多阶段咨询，但不提供药物治疗，但利用率低，损耗大。这项研究的目的是确定免费的尼古丁替代疗法（NRT），有关主动吸烟者戒烟尝试和6个月戒烟率的简要建议和自助材料的有效性。方法在这项开放标签的自然研究中，加拿大安大略省所有合格的成年吸烟者均可使用14000疗程，持续5周尼古丁贴剂（n = 10000）或尼古丁口香糖（n = 4000）。免费号码可注册STOP（安大略省患者的吸烟治疗）研究并接受一次简短干预。主要结果指标是STOP参与者在治疗后6个月自我报告的戒断率。将这些数据与同时符合资格的安大略省吸烟者无干预队列中报告的戒烟率进行了比较。结果对16405名呼叫者进行了评估，并向13143名符合条件的参与者邮寄了5周NRT（贴片或口香糖选择），自助和社区资源材料的治疗包。在接受随访的6261名参与者中，有2601名（42％）具有完整的随访数据。在具有完整随访数据的患者中，治疗队列中6个月后报告戒酒的百分比为21.4％，相对于无干预队列中11.6％的比率（比率为1.84； 95％Cl为1.79至1.89），其中干预组和无干预组的30天患病率分别为17.8％和9.8％（比率1.81； CI 1.75至1.87）。结论在简短的电话干预之后，通过邮件提供免费的NR​​T是一种有效的策略，可以吸引并协助大量吸烟者戒烟。

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  • 来源
    《Tobacco control》 |2013年第3期|216|共1页
  • 作者

    Laurie Zawertailo; Rosa Dragonetti; Susan J Bondy; J Charles Victor; Peter Selby;

  • 作者单位

    Addictions Program, Nicotine Dependence Clinic, Centre for Addiction and Mental Health,Toronto, Ontario, Canada,Department of Pharmacology and Toxicology, University of Toronto, Toronto, Ontario,Canada;

    Addictions Program, Nicotine Dependence Clinic, Centre for Addiction and Mental Health,Toronto, Ontario, Canada;

    Dalla Lana School of Public Health, University of Toronto,Toronto, Ontario, Canada,Ontario Tobacco Research Unit,Toronto, Ontario, Canada;

    Ontario Tobacco Research Unit,Toronto, Ontario, Canada,Institute of Health Policy Management and Evaluation,Toronto, Ontario, Canada;

    Addictions Program, Nicotine Dependence Clinic, Centre for Addiction and Mental Health,Toronto, Ontario, Canada,Dalla Lana School of Public Health, University of Toronto,Toronto, Ontario, Canada,Ontario Tobacco Research Unit,Toronto, Ontario, Canada,Department of Family and Community Medicine, University of Toronto, Toronto, Ontario,Canada,Department of Psychiatry,University of Toronto, Toronto,Ontario, Canada;

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