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首页> 外文期刊>Translational Stroke Research >Inhaled Nitric Oxide Protects Males But not Females from Neonatal Mouse Hypoxia–Ischemia Brain Injury
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Inhaled Nitric Oxide Protects Males But not Females from Neonatal Mouse Hypoxia–Ischemia Brain Injury

机译：吸入一氧化氮可保护男性免受新生小鼠缺氧缺血性脑损伤的侵害，但不能保护女性

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摘要

It was recently discovered that while under normal conditions inhaled nitric oxide (iNO) does not affect cerebral blood flow, it selectively dilates arterioles in the ischemic penumbra during experimental cerebral ischemia, thereby increasing collateral blood flow and reducing ischemic brain damage. The mechanism was verified in multiple models, but only in male animals. Our aim was to evaluate the effects of iNO on brain injury in neonatal males and females. Nine-day-old mice were subjected to unilateral hypoxia–ischemia (HI), using 10 % oxygen balanced with nitrogen, with or without 50 ppm NO. Brain injury 72 h after HI was reduced by iNO as judged by percentage of injury (−21.7 %), atrophy (−23.7 %), and total pathological score (−29 %). The injury was significantly reduced in males (−32.4 %, p < 0.05) but not in females (−7.1 %, n.s.). Neither the numbers nor the proliferation rates of neural stem cells in the dentate gyrus were affected by iNO. In summary, intraischemic iNO reduced neonatal HI brain injury in a gender-related manner.
机译：最近发现，虽然在正常条件下吸入一氧化氮（iNO）不会影响脑血流，但它在实验性脑缺血期间选择性地扩张了缺血半影中的小动脉，从而增加了侧支血流并减少了缺血性脑损伤。该机制已在多种模型中得到验证，但仅在雄性动物中得到了验证。我们的目的是评估iNO对新生男性和女性脑损伤的影响。对9日龄的小鼠进行单侧缺氧缺血（HI），使用10％的氧气和氮气平衡，有或没有50 ppm的NO。根据损伤百分比（−21.7％），萎缩（−23.7％）和总病理评分（−29％）判断，iNO使HI后72小时的脑损伤减少。男性的伤害显着降低（−32.4％，p <0.05），而女性没有显着降低（−7.1％，未发现）。齿状回中神经干细胞的数量和增殖率均不受iNO影响。总之，缺血内iNO以性别相关的方式减少了新生儿HI脑损伤。

著录项

  • 来源
    《Translational Stroke Research》 |2013年第2期|201-207|共7页
  • 作者

    Changlian Zhu; Yanyan Sun; Jianfeng Gao; Xiaoyang Wang; Nikolaus Plesnila; Klas Blomgren;

  • 作者单位

    Center for Brain Repair and Rehabilitation Institute of Neuroscience and Physiology Sahlgrenska Academy University of Gothenburg">(1);

    Department of Pediatrics The Third Affiliated Hospital of Zhengzhou University">(2);

    Center for Brain Repair and Rehabilitation Institute of Neuroscience and Physiology Sahlgrenska Academy University of Gothenburg">(1);

    Department of Pediatrics The Third Affiliated Hospital of Zhengzhou University">(2);

    Department of Pediatrics Zhengzhou Children’s Hospital">(3);

    Center for Brain Repair and Rehabilitation Institute of Neuroscience and Physiology Sahlgrenska Academy University of Gothenburg">(1);

    Department of Physiology Henan Chinese Medical College">(4);

    Department of Pediatrics The Third Affiliated Hospital of Zhengzhou University">(2);

    Perinatal Center Institute of Neuroscience and Physiology Sahlgrenska Academy University of Gothenburg">(5);

    Institute for Stroke and Dementia Research University of Munich Medical School">(6);

    Center for Brain Repair and Rehabilitation Institute of Neuroscience and Physiology Sahlgrenska Academy University of Gothenburg">(1);

    Department of Pediatrics Queen Silvia Children’s Hospital University of Gothenburg">(7);

    Department of Women’s and Children’s Health Karolinska Institute Karolinska University Hospital">(8);

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  • 原文格式 PDF
  • 正文语种 eng
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  • 关键词

    Gender difference; Asphyxia; Neonate; Neuroprotection; Nitric oxide; Microglia;

    机译：性别差异;窒息;新生儿神经保护;一氧化氮;小胶质细胞;

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