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首页> 外文期刊>Translational Stroke Research >Phenotypic Changes in Immune Cell Subsets Reflect Increased Infarct Volume in Male vs. Female Mice
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Phenotypic Changes in Immune Cell Subsets Reflect Increased Infarct Volume in Male vs. Female Mice

机译：免疫细胞亚型的表型变化反映了雄性和雌性小鼠的梗死体积增加

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摘要

Inflammatory responses in the brain after cerebral ischemia have been studied extensively in male mice, but not female mice, thus potentially giving a less-than-accurate view of gender associated pathological processes. In humans, cerebral infarcts are typically smaller in premenopausal females than in age-matched males. In the current study, we confirmed smaller infarcts in female vs. male mice after middle cerebral artery occlusion and 96 h of reperfusion. Moreover, we explored immunological alterations related to this difference and found that the percentage of CD4+ T lymphocytes was significantly higher in spleens in males than females, with increased expression of the activation markers, CD69 and CD44. In contrast, the percentage of CD8+ T lymphocytes was significantly higher in spleens of females than males, leading to the identification of a small but distinct population of IL-10-secreting CD8+CD122+ suppressor T cells that were also increased in females. Finally, we observed that males have a greater percentage of activated macrophages/microglia in the brain than females, as well as increased expression of the VLA-4 adhesion molecule in both brain and spleen. This new information suggesting gender-dependent immunological mechanisms in stroke implies that effective treatments for human stroke may also be gender specific.
机译：已经在雄性小鼠而非雌性小鼠中广泛研究了脑缺血后大脑中的炎症反应，因此潜在地给出了与性别相关的病理过程的不太准确的观点。在人类中，绝经前女性的脑梗塞通常比年龄匹配的男性小。在目前的研究中，我们证实大脑中动脉闭塞和再灌注96小时后，雌性和雄性小鼠的梗死面积较小。此外，我们探索了与这种差异相关的免疫学改变，发现男性脾脏中CD4 + T淋巴细胞的百分比显着高于女性，且激活标记CD69和CD44的表达增加。相反，女性脾脏中CD8 + T淋巴细胞的百分比显着高于男性，导致鉴定出少量但截然不同的IL-10分泌CD8 + CD122 +抑制性T细胞，女性中也有所增加。最后，我们观察到，男性在大脑中的活化巨噬细胞/小胶质细胞百分比高于女性，并且在大脑和脾脏中VLA-4粘附分子的表达增加。这一新的信息表明中风的性别依赖性免疫机制暗示着对人中风的有效治疗也可能是针对性别的。

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  • 来源
    《Translational Stroke Research》 |2013年第5期|554-563|共10页
  • 作者

    Anirban Banerjee; Jianming Wang; Sheetal Bodhankar; Arthur A. Vandenbark; Stephanie J. Murphy; Halina Offner;

  • 作者单位

    Neuroimmunology Research Portland Veterans Affairs Medical Center">(1);

    Department of Neurology Oregon Health and Science University">(2);

    Department of Anesthesiology and Perioperative Medicine Oregon Health and Science University">(3);

    Neuroimmunology Research Portland Veterans Affairs Medical Center">(1);

    Department of Neurology Oregon Health and Science University">(2);

    Neuroimmunology Research Portland Veterans Affairs Medical Center">(1);

    Department of Neurology Oregon Health and Science University">(2);

    Department of Molecular Microbiology and Immunology Oregon Health and Science University">(4);

    Department of Anesthesiology and Perioperative Medicine Oregon Health and Science University">(3);

    Neuroimmunology Research Portland Veterans Affairs Medical Center">(1);

    Department of Neurology Oregon Health and Science University">(2);

    Department of Anesthesiology and Perioperative Medicine Oregon Health and Science University">(3);

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  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类
  • 关键词

    Experimental stroke; Gender bias; Immune markers; Activated T cells; Suppressor T cells; Ischemia;

    机译：实验性中风;性别偏见;免疫标记活化的T细胞;抑制性T细胞;缺血;

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