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首页> 外文期刊>Translational Stroke Research >Deferoxamine Reduces Neuronal Death and Hematoma Lysis After Intracerebral Hemorrhage in Aged Rats
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Deferoxamine Reduces Neuronal Death and Hematoma Lysis After Intracerebral Hemorrhage in Aged Rats

机译：去铁胺降低老年大鼠脑出血后神经元死亡和血肿溶解

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摘要

Intracerebral hemorrhage (ICH) is primarily a disease of the elderly. Deferoxamine (DFX), an iron chelator, reduces long-term neurological deficits and brain atrophy after ICH in aged rats. In the present study, we investigated whether DFX can reduce acute ICH-induced neuronal death and whether it affects the endogenous response to ICH (ferritin upregulation and hematoma resolution) in aged rats. Male Fischer 344 rats (18 months old) had an intracaudate injection of 100 μL autologous whole blood into the right basal ganglia and were treated with DFX (100 mg/kg) or vehicle 2 h post-ICH and then every 12 h up to 7 days. Rats were euthanized 1, 3, or 7 days later for neuronal death and ferritin and hematoma size measurements. Plasma ferritin levels and behavioral outcome following ICH were also examined. DFX treatment significantly reduced ICH-induced neuronal death and neurological deficits. DFX also suppressed ferritin upregulation in the ipsilateral basal ganglia after ICH and hematoma lysis (hematoma volume at day 7, 13.2 ± 4.9 vs. 3.8 ± 1.2 mm3 in vehicle-treated group, p < 0.01). However, effects of DFX on plasma ferritin levels after ICH did not reach significance. In conclusion, DFX reduces neuronal death and neurological deficits after ICH in aged rats. It also affects the endogenous response to ICH.
机译：脑出血（ICH）主要是老年人的疾病。铁螯合剂Deferoxamine（DFX）可减少老年大鼠ICH后的长期神经功能缺损和脑萎缩。在本研究中，我们调查了DFX是否可以减少老年大鼠的ICH急性神经元死亡，以及它是否影响ICH的内源性反应（铁蛋白上调和血肿消退）。雄性Fischer 344大鼠（18个月大）向右基底神经节尾内注射100μL自体全血，并在ICH后2小时用DFX（100 mg / kg）或媒介物治疗，然后每12 h最多治疗7天。在1、3或7天后对大鼠实施安乐死以进行神经元死亡以及铁蛋白和血肿大小的测量。还检查了ICH后血浆铁蛋白水平和行为预后。 DFX治疗显着降低了ICH诱导的神经元死亡和神经功能缺损。 DFX还抑制了ICH和血肿溶解后同侧基底神经节中铁蛋白的上调（第7天血肿体积为13.2±±4.9 mm3，而媒介物治疗组为3.8±±1.2 mm3，p <0.01）。然而，ICH后DFX对血浆铁蛋白水平的影响未达到显着水平。总之，DFX可以降低老年大鼠ICH后的神经元死亡和神经功能缺损。它还影响对ICH的内源性反应。

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