首页> 外文期刊>Translational Stroke Research >Pseudo-Continuous Arterial Spin Labelling MRI for Non-Invasive, Whole-Brain, Serial Quantification of Cerebral Blood Flow Following Aneurysmal Subarachnoid Haemorrhage
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Pseudo-Continuous Arterial Spin Labelling MRI for Non-Invasive, Whole-Brain, Serial Quantification of Cerebral Blood Flow Following Aneurysmal Subarachnoid Haemorrhage

机译:伪连续动脉自旋标记核磁共振成像用于无创,全脑,连续定量的动脉瘤性蛛网膜下腔出血后脑血流

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摘要

Delayed cerebral ischaemia (DCI) is the major cause of mortality and morbidity following aneurysmal subarachnoid haemorrhage (SAH). Recent experimental evidence from animal models has highlighted the need for non-invasive and robust measurements of brain tissue perfusion in patients in order to help understand the pathophysiology underlying DCI. Quantitative, serial, whole-brain cerebral perfusion measurements were obtained with pseudo-continuous arterial spin labelling (PCASL) magnetic resonance imaging (MRI) in six SAH patients acutely following endovascular coiling. This technique requires no injected contrast or radioactive isotopes. MRI scanning was well tolerated. Artefact from endovascular coils was minimal. PCASL MRI was able to detect time-dependent and patient-specific changes in voxel-wise and regional cerebral blood flow. These changes reflected changes in clinical condition. Data obtained in healthy controls using the same experimental protocol confirm the reliability and reproducibility of these results. This is the first study to use whole-brain, quantitative PCASL to identify time-dependent changes in cerebral blood flow at the tissue level in the acute period following SAH. This technique has the potential to better understand changes in cerebral pathophysiology as a consequence of aneurysm rupture.
机译:延迟性脑缺血(DCI)是动脉瘤性蛛网膜下腔出血(SAH)后死亡和发病的主要原因。来自动物模型的最新实验证据强调,需要对患者的脑组织灌注进行非侵入性和稳健的测量,以帮助了解DCI的病理生理学。在6名SAH患者中,在血管内盘绕后,通过伪连续动脉自旋标记(PCASL)磁共振成像(MRI)获得了定量,连续,全脑的脑灌注测量。该技术不需要注入造影剂或放射性同位素。 MRI扫描耐受良好。来自血管内线圈的伪影极少。 PCASL MRI能够检测体素和局部脑血流的时间依赖性和患者特异性变化。这些变化反映了临床状况的变化。使用相同实验方案在健康对照组中获得的数据证实了这些结果的可靠性和可重复性。这是首次使用全脑定量PCASL来确定SAH急性期后组织水平的脑血流的时间依赖性变化的研究。这种技术有可能更好地了解由于动脉瘤破裂而引起的脑病理生理学变化。

著录项

  • 来源
    《Translational Stroke Research》 |2013年第6期|710-718|共9页
  • 作者单位

    Nuffield Department of Clinical Neurosciences and Oxford Acute Vascular Imaging Centre University of Oxford John Radcliffe Hospital">(1);

    Nuffield Department of Clinical Neurosciences and Oxford Acute Vascular Imaging Centre University of Oxford John Radcliffe Hospital">(1);

    Neurointensive Care Oxford University Hospitals NHS Trust">(2);

    Nuffield Department of Clinical Neurosciences and Oxford Acute Vascular Imaging Centre University of Oxford John Radcliffe Hospital">(1);

    Institute of Biomedical Engineering University of Oxford">(3);

    Neurointensive Care Oxford University Hospitals NHS Trust">(2);

    Neurointensive Care Oxford University Hospitals NHS Trust">(2);

    Nuffield Department of Clinical Neurosciences and Oxford Acute Vascular Imaging Centre University of Oxford John Radcliffe Hospital">(1);

    Neurointensive Care Oxford University Hospitals NHS Trust">(2);

    Nuffield Department of Clinical Neurosciences and Oxford Acute Vascular Imaging Centre University of Oxford John Radcliffe Hospital">(1);

    Nuffield Department of Clinical Neurosciences and Oxford Acute Vascular Imaging Centre University of Oxford John Radcliffe Hospital">(1);

    Neurointensive Care Oxford University Hospitals NHS Trust">(2);

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  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类
  • 关键词

    Aneurysmal subarachnoid haemorrhage; Delayed cerebral ischaemia; Arterial spin labelling; Magnetic resonance imaging;

    机译:动脉瘤性蛛网膜下腔出血;迟发性脑缺血;动脉旋转标记;磁共振成像;

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